This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Flag-Keap1
catalog :
28023
citations: 10
Reference
Aboulkassim T, Tian X, Liu Q, Qiu D, Hancock M, Wu J, et al. A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Cell Rep. 2023;42:113104 pubmed publisher
Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, et al. SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway. Cell Death Dis. 2023;14:361 pubmed publisher
Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li Ma C, Ko Y, et al. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. bioRxiv. 2023;: pubmed publisher
Vasavda C, Xu R, Liew J, Kothari R, Dhindsa R, Semenza E, et al. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022;8:eabo5633 pubmed publisher
Piao J, Kim S, Kim D, Park J, Park S, Han H, et al. Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach. Sci Rep. 2020;10:15711 pubmed publisher
Luo A, Chen Y. Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2. J Proteome Res. 2020;19:260-268 pubmed publisher
Ji L, Zhang R, Chen J, Xue Q, Moghal N, Tsao M. PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC. Sci Rep. 2019;9:12437 pubmed publisher
Bollong M, Lee G, Coukos J, Yun H, Zambaldo C, Chang J, et al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018;562:600-604 pubmed publisher
Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, et al. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy. 2010;6:614-21 pubmed publisher
product information
Catalog Number :
28023
Product Name :
Flag-Keap1
article :
doi10.4161/auto.6.5.12189
id4025
pubmed_id20495340
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA/FRT/TO
backbone_mutation
backbone_originInvitrogen
backbone_size5137
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5BamHI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesINrf2, KLHL19
geneKEAP1
id9817
genbank_ids
mutation
nameKeap1
shRNA_sequence
size1847
species
9606
Homo sapiens
tags
locationC terminal on insert
tag3xFlag
resistance markers :
696
tags :
High Copy
terms :
Hygromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA