This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Mfn2-YFP
catalog :
28010
citations: 13
Reference
S xe1 Pessoa J, L xf3 pez Montesino S, Przybyszewska K, Rodr xed guez Escudero I, Marshall H, Ova A, et al. A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection. Nat Commun. 2023;14:871 pubmed publisher
Zhou J, Liu H, Zhang T, Wang Z, Zhang J, Lu Y, et al. MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy. Free Radic Biol Med. 2023;196:156-170 pubmed publisher
Márquez Nogueras K, Vuchkovska V, DiNello E, Osorio Valencia S, Kuo I. Polycystin-2 (PC2) is a key determinant of in-vitro myogenesis. Am J Physiol Cell Physiol. 2022;: pubmed publisher
Tanwar J, Saurav S, Basu R, Singh J, Priya A, Dutta M, et al. Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation. Cells. 2022;11: pubmed publisher
Baek M, Choe Y, Bannwarth S, Kim J, Maitra S, Dorn G, et al. TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro. Nat Commun. 2021;12:1924 pubmed publisher
Delmotte P, Marin Mathieu N, Sieck G. TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2021;320:L137-L151 pubmed publisher
Du M, Yu S, Su W, Zhao M, Yang F, Liu Y, et al. Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation. J Cell Sci. 2020;133: pubmed publisher
Fessler E, Eckl E, Schmitt S, Mancilla I, Meyer Bender M, Hanf M, et al. A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol. Nature. 2020;579:433-437 pubmed publisher
Gao J, Qin A, Liu D, Ruan R, Wang Q, Yuan J, et al. Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv. 2019;5:eaaw7215 pubmed publisher
Fang D, Yan S, Yu Q, Chen D, Yan S. Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons. Sci Rep. 2016;6:31462 pubmed publisher
Lim G, Chew K, Ng X, Henry Basil A, Sim R, Tan J, et al. Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination. PLoS ONE. 2013;8:e73235 pubmed publisher
Zhang G, Jin H, Lin X, Chen C, Liu X, Zhang Q, et al. Anti-tumor effects of Mfn2 in gastric cancer. Int J Mol Sci. 2013;14:13005-21 pubmed publisher
Karbowski M, Lee Y, Gaume B, Jeong S, Frank S, Nechushtan A, et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 2002;159:931-8 pubmed
product information
Catalog Number :
28010
Product Name :
Mfn2-YFP
article :
doi10.1083/jcb.200209124
id4020
pubmed_id12499352
bacterial resistance :
Kanamycin
cloning :
backboneYFP-N1
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Santel, A. and M.T. Fuller, Control of mitochondrial morphology by a human mitofusin. J Cell Sci, 2001. 114(Pt 5): p. 867-74.
origin :
37
pi :
alt_names
Mfn2
cloning
clone_methodRestriction Enzyme
cloning_site_3BamH1
cloning_site_5EcoRI
promoter
sequencing_primer_3
sequencing_primer_5AGGTCTATATAAGCAGAGC
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, MARF, MSL
geneMFN2
id9927
genbank_ids
NM_014874
mutationsilent S508S
namemitofusin 2
shRNA_sequence
size2282
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagYFP
plasmid copy :
cloned from Mfn2-GFP: Santel and Fuller, 2001
resistance markers :
604
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA