This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pOPTN-EGFP
catalog :
27052
citations: 13
Reference
Mishra D, Narain P, Dave U, Gomes J. Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation. Mol Cell Neurosci. 2023;127:103904 pubmed publisher
Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, et al. Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun. 2023;14:4084 pubmed publisher
Li H, Lismont C, Costa C, Hussein M, Baes M, Fransen M. Enhanced Levels of Peroxisome-Derived H2O2 Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells. Antioxidants (Basel). 2023;12: pubmed publisher
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher
Cazzaro S, Fang C, Khan H, Witas R, Kee T, Woo J, et al. Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics. Front Aging Neurosci. 2022;14:933979 pubmed publisher
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher
Ye J, Cheung J, Gerbino V, Ahlsen G, Zimanyi C, Hirsh D, et al. Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity. Proc Natl Acad Sci U S A. 2019;116:24517-24526 pubmed publisher
Bowling J, Skolfield M, Riley W, Nolin A, Wolf L, Nelson D. Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway. BMC Mol Cell Biol. 2019;20:33 pubmed publisher
Xu Y, Zhang S, Zheng H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019;15:583-598 pubmed publisher
Zhang Y, Guo X, Yan W, Chen Y, Ke M, Cheng C, et al. ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ. Nat Commun. 2017;8:2164 pubmed publisher
Schmuckli Maurer J, Reber V, Wacker R, Bindschedler A, Zakher A, Heussler V. Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane. PLoS ONE. 2017;12:e0183797 pubmed publisher
Montecalvo A, Watkins S, Orange J, Kane L. Inducible turnover of optineurin regulates T cell activation. Mol Immunol. 2017;85:9-17 pubmed publisher
Park B, Shen X, Samaraweera M, Yue B. Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types. Am J Pathol. 2006;169:1976-89 pubmed
product information
Catalog Number :
27052
Product Name :
pOPTN-EGFP
article :
doi10.2353/ajpath.2006.060400
id3851
pubmed_id17148662
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-N1
backbone_mutation
backbone_originClonetech
backbone_size4733
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
OPTN
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5ECoRI
promoter
sequencing_primer_3sequence
sequencing_primer_5sequence
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
geneOPTN
id10133
genbank_ids
NM_001008211
mutation
nameoptineurin
shRNA_sequence
size1738
species
9606
Homo sapiens
tags
plasmid copy :
Dr. Robert Weil, Institute Pasteur, Paris, France
resistance markers :
862
tags :
Unknown
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA