This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
deltaNp63alpha-FLAG
catalog :
26979
citations: 17
Reference
Fisher M, Balinth S, Hwangbo Y, Wu C, Ballon C, Goldberg G, et al. Cancer associated fibroblasts promote cancer stemness by inducing expression of the chromatin modifying protein CBX4 in squamous cell carcinoma. Carcinogenesis. 2023;: pubmed publisher
Sasamoto Y, Lee C, Wilson B, Buerger F, Martin G, Mishra A, et al. Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022;40:111166 pubmed publisher
Pinnamaneni J, Singh V, Kim M, Ryan C, Pugazenthi A, Sanagasetti D, et al. p63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation. Sci Rep. 2022;12:11416 pubmed publisher
Van Sciver N, Ohashi M, Nawandar D, Pauly N, Lee D, Makielski K, et al. ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells. PLoS Pathog. 2021;17:e1010045 pubmed publisher
Fisher M, Balinth S, Hwangbo Y, Wu C, Ballon C, Wilkinson J, et al. BRD4 Regulates Transcription Factor ΔNp63α to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas. Cancer Res. 2021;81:6246-6258 pubmed publisher
Westcott J, Camacho S, Nasir A, Huysman M, Rahhal R, Dang T, et al. ΔNp63 regulated epithelial-to-mesenchymal transition state heterogeneity confers a leader-follower relationship that drives collective invasion. Cancer Res. 2020;: pubmed publisher
Zheng J, Yun W, Park J, Kang P, Lee G, Song G, et al. Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin. J Biomed Sci. 2020;27:56 pubmed publisher
Okada Y, Zhang Y, Zhang L, Yeh L, Wang Y, Saika S, et al. Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis. Lab Invest. 2019;: pubmed publisher
Somerville T, Xu Y, Miyabayashi K, Tiriac H, Cleary C, Maia Silva D, et al. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep. 2018;25:1741-1755.e7 pubmed publisher
Jiang Y, Jiang Y, Xie J, Mayakonda A, Hazawa M, Chen L, et al. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018;9:3619 pubmed publisher
Lin Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson C, et al. KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. Genes Dev. 2018;32:181-193 pubmed publisher
Porteiro B, Fondevila M, Delgado T, Iglesias C, Imbernon M, Iruzubieta P, et al. Hepatic p63 regulates steatosis via IKKβ/ER stress. Nat Commun. 2017;8:15111 pubmed publisher
Wang X, Boddicker R, Dasari S, Sidhu J, Kadin M, Macon W, et al. Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping. Hum Pathol. 2017;64:19-27 pubmed publisher
Di Franco S, Turdo A, Benfante A, Colorito M, Gaggianesi M, Apuzzo T, et al. ?Np63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. Oncotarget. 2016;7:54157-54173 pubmed publisher
Cam M, Gardner H, Roberts R, Fenger J, Guttridge D, London C, et al. ΔNp63 mediates cellular survival and metastasis in canine osteosarcoma. Oncotarget. 2016;7:48533-48546 pubmed publisher
Yang K, Wu W, Chen Y, Lo S, Liao Y. ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion. PLoS ONE. 2016;11:e0147542 pubmed publisher
Chatterjee A, Upadhyay S, Chang X, Nagpal J, Trink B, Sidransky D. U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of DeltaNp63alpha. Cell Cycle. 2008;7:1231-7 pubmed
product information
Catalog Number :
26979
Product Name :
deltaNp63alpha-FLAG
article :
doi10.4161/cc.7.9.5795
id3833
pubmed_id18418053
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1/hygro
backbone_mutation
backbone_originInvitrogen
backbone_size5597
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Addgene's quality control sequence shows an S59G mutation in the insert. The depositing lab does not believe this mutation affects function.
origin :
37
pi :
alt_names
p63
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5BamHI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
geneTP63
id8626
genbank_ids
mutationdominant negative isoform of p63; aa 1 587
name NP63alpha
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagFLAG
resistance markers :
479
tags :
High Copy
terms :
Hygromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA