This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
CaV 2 1
catalog :
26575
citations: 18
Reference
Chin M, Kaeser P. The intracellular C-terminus confers compartment-specific targeting of voltage-gated Ca2+ channels. bioRxiv. 2023;: pubmed publisher
He L, Qi Y, Allard C, Valencia Montoya W, Krueger S, Weir K, et al. Molecular tuning of sea anemone stinging. elife. 2023;12: pubmed publisher
Castro Junior C, Gomez M, Borges M, Lipscombe D, Andrade A. ω-Phonetoxins inhibit voltage-gated calcium CaV2.2 ion channel splice isoforms of dorsal root ganglia. bioRxiv. 2023;: pubmed publisher
Rodan L, Spillmann R, Kurata H, Lamothe S, Maghera J, Jamra R, et al. Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genet Med. 2021;: pubmed publisher
Ferrante D, Sterlini B, Prestigio C, Marte A, Corradi A, Onofri F, et al. PRRT2 modulates presynaptic Ca2+ influx by interacting with P/Q-type channels. Cell Rep. 2021;35:109248 pubmed publisher
Ojala K, Ginebaugh S, Wu M, Miller E, Ortiz G, Covarrubias M, et al. A high affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J Biol Chem. 2021;:100302 pubmed publisher
Chen H, Vandorpe D, Xie X, Alper S, Zeidel M, Yu W. Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology. Nat Commun. 2020;11:4328 pubmed publisher
Li B, He X, Dong Z, Xuan K, Sun W, Gao L, et al. Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca2+ channel internalization in mesenchymal stem cells. Bone Res. 2020;8:19 pubmed publisher
Martinez San Segundo P, Terni B, Burgueno J, Monroy X, Dordal A, Merlos M, et al. Outside-in regulation of the readily releasable pool of synaptic vesicles by α2δ-1. FASEB J. 2020;34:1362-1377 pubmed publisher
Vierra N, Kirmiz M, van der List D, Santana L, Trimmer J. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons. elife. 2019;8: pubmed publisher
Jiang X, Raju P, D Avanzo N, Lachance M, Pepin J, Dubeau F, et al. Both gain-of-function and loss-of-function de novo CACNA1A mutations cause severe developmental epileptic encephalopathies in the spectrum of Lennox-Gastaut syndrome. Epilepsia. 2019;60:1881-1894 pubmed publisher
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, et al. Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity. Neuron. 2019;: pubmed publisher
Royer L, Herzog J, Kenny K, Tzvetkova B, Cochrane J, Marr M, et al. The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity. J Biol Chem. 2018;293:14798-14811 pubmed publisher
Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, et al. A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. J Neurosci. 2018;38:5551-5566 pubmed publisher
Bellono N, Leitch D, Julius D. Molecular basis of ancestral vertebrate electroreception. Nature. 2017;543:391-396 pubmed publisher
Ruchala I, Cabra V, Solis E, Glennon R, De Felice L, Eltit J. Electrical coupling between the human serotonin transporter and voltage-gated Ca(2+) channels. Cell Calcium. 2014;56:25-33 pubmed publisher
Jiang Y, Andrade A, Lipscombe D. Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA. Mol Pain. 2013;9:67 pubmed publisher
Lin Y, McDonough S, Lipscombe D. Alternative splicing in the voltage-sensing region of N-Type CaV2.2 channels modulates channel kinetics. J Neurophysiol. 2004;92:2820-30 pubmed
product information
Catalog Number :
26575
Product Name :
CaV 2 1
article :
doi10.1152/jn.00048.2004
id3698
pubmed_id15201306
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1/Hygro
backbone_mutation
backbone_originInvitrogen
backbone_size5600
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
GENBANK #AF286488
growth temp :
TOP10F'
inserts :
Top10F'
origin :
37
pi :
alt_names
voltage-gated calcium channel alpha2/delta-1 subunit
cloning
clone_methodRestriction Enzyme
cloning_site_3ApaI
cloning_site_5NotI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCCHLA2, Cacna2, DHSCCA
geneCacna2d1
id25399
genbank_ids
mutation
nameCacna2d1
shRNA_sequence
size3965
species
10116
Rattus norvegicus
tags
resistance markers :
813
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA