This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3-AU1-mTOR-S2215Y
catalog :
26037
citations: 4
Reference
Fan Q, Aksoy O, Wong R, Ilkhanizadeh S, Novotny C, Gustafson W, et al. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017;31:424-435 pubmed publisher
Welte T, Kim I, Tian L, Gao X, Wang H, Li J, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016;18:632-44 pubmed publisher
Havel J, Li Z, Cheng D, Peng J, Fu H. Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene. 2015;34:1487-98 pubmed publisher
Sato T, Nakashima A, Guo L, Coffman K, Tamanoi F. Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene. 2010;29:2746-52 pubmed publisher
product information
Catalog Number :
26037
Product Name :
pcDNA3-AU1-mTOR-S2215Y
article :
doi10.1038/onc.2010.28
id3592
pubmed_id20190810
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
mTOR
cloning
clone_methodRestriction Enzyme
cloning_site_3Not I
cloning_site_5Hind III
promoter
sequencing_primer_3Sp6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesFrap1, RAFT1
geneMtor
id56718
genbank_ids
mutationS2215Y
namemammalian target of rapamycin-S2215Y
shRNA_sequence
size7700
species
10116
Rattus norvegicus
tags
locationN terminal on backbone
tagAU1
resistance markers :
517
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA