This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCR4-huNFATc1nuc
catalog :
23988
citations: 3
| Reference |
|---|
Winslow M, Pan M, Starbuck M, Gallo E, Deng L, Karsenty G, et al. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006;10:771-82 pubmed
|
product information
Catalog Number :
23988
Product Name :
pCR4-huNFATc1nuc
article :
| doi | 10.1016/j.devcel.2006.04.006 |
| id | 2777 |
| pubmed_id | 16740479 |
bacterial resistance :
Ampicillin
cloning :
| backbone | pCR4 | ||
| backbone_mutation | |||
| backbone_origin | |||
| backbone_size | 4000 | ||
| promoter | |||
| sequencing_primer_3 | |||
| sequencing_primer_5 | |||
| vector_types |
|
growth notes :
The c1nuc plasmid expresses the constitutively nuclear form of NFATc1 (Ho et al Nature 2004). It contains mutations in the phosphorylation sites for Dyrk1a and GSK3 that are responsible for actively exporting the protein from the nucleus (Beal et al Science 1997; Arron et al Nature 2006). It can be used as a transgene to explore NFAT signaling (Winslow et al Dev Cell 2006) and when expressed in a specific tissue can direct events such as bone development, thymocyte development or pancreatic beta cell functions (Heit J et al Nature 2007).
origin :
37
pi :
|
resistance markers :
| 97 |
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
Watertown, MA 02472
info@addgene.org
https://www.addgene.org617.225.9000
headquarters: USA
questions and comments