This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pDONR223-ERBB3
catalog :
23874
citations: 10
Reference
Stern Y, Al Ghabkari A, Monast A, Fiset B, Aboualizadeh F, Yao Z, et al. Met-HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells. Cell Mol Life Sci. 2022;79:178 pubmed publisher
Campbell M, Ruiz Sáenz A, Zhang Y, Peterson E, Steri V, Oeffinger J, et al. Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling. Cell Rep. 2022;38:110285 pubmed publisher
Campbell M, Ruiz Sáenz A, Peterson E, Agnew C, Ayaz P, Garfinkle S, et al. Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Cell Rep. 2022;38:110291 pubmed publisher
Al Akhrass H, Conway J, Poulsen A, Paatero I, Kaivola J, Padzik A, et al. A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene. 2021;: pubmed publisher
Brand T, Hartmann S, Bhola N, Li H, Zeng Y, O Keefe R, et al. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res. 2018;78:2383-2395 pubmed publisher
Werbin J, Avendaño M, Becker V, Jungmann R, Yin P, Danuser G, et al. Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Sci Rep. 2017;7:12150 pubmed publisher
Brand T, Hartmann S, Bhola N, Peyser N, Li H, Zeng Y, et al. Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients. Clin Cancer Res. 2017;23:3072-3083 pubmed publisher
Fowler D, Stewart S, Seredick S, Eisen J, Stankunas K, Washbourne P. A MultiSite Gateway Toolkit for Rapid Cloning of Vertebrate Expression Constructs with Diverse Research Applications. PLoS ONE. 2016;11:e0159277 pubmed publisher
Safavi S, Järnum S, Vannas C, Udhane S, Jonasson E, Tomić T, et al. HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. Oncotarget. 2016;7:433-45 pubmed publisher
Johannessen C, Boehm J, Kim S, Thomas S, Wardwell L, Johnson L, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468:968-72 pubmed publisher
product information
Catalog Number :
23874
Product Name :
pDONR223-ERBB3
article :
doi10.1038/nature09627
id3878
pubmed_id21107320
bacterial resistance :
Spectinomycin
cloning :
backbonepDONR223
backbone_mutation
backbone_originInvitrogen
backbone_size5005
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Other
Gateway Donor vector
growth notes :
The ORF has no Stop codon. This design enables easy recombination into a destination vector to add an epitope tag of choice and Stop codon to the ORF. Do NOT use this plasmid directly for transfections. A set of 4 custom lentiviral vectors is available ( pLX301 (http://www.addgene.org/25895/) , pLX302 (http://www.addgene.org/25896/) , pLX303 (http://www.addgene.org/25897/) , pLX304 (http://www.addgene.org/25890/) ) to be used to express these ORFs in mammalian cells. These plasmids are not included in the kit and must be ordered separately.
origin :
37
pi :
alt_names
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3M13rev
sequencing_primer_5M13pUC-fwd
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesErbB-3, FERLK, HER3, LCCS2, MDA-BF-1, VSCN1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
geneERBB3
id2065
genbank_ids
mutation
nameERBB3
shRNA_sequence
size4029
species
9606
Homo sapiens
tags
resistance markers :
184
423
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA