This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
hIR-GFP
catalog :
22286
citations: 9
Reference
Khurshid S, Montes M, Comiskey D, Shane B, Matsa E, Jung F, et al. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022;6:1 pubmed publisher
Zhao N, Liu C, Van Ingelgom A, Martens Y, Linares C, Knight J, et al. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017;96:115-129.e5 pubmed publisher
Chan J, Hackel B, Yee D. Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds. Mol Cancer Ther. 2017;16:1324-1334 pubmed publisher
Chawla B, Hedman A, Sayedyahossein S, Erdemir H, Li Z, Sacks D. Absence of IQGAP1 Protein Leads to Insulin Resistance. J Biol Chem. 2017;292:3273-3289 pubmed publisher
Petersen M, Madiraju A, Gassaway B, Marcel M, Nasiri A, Butrico G, et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest. 2016;126:4361-4371 pubmed publisher
Nagarajan A, Petersen M, Nasiri A, Butrico G, Fung A, Ruan H, et al. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun. 2016;7:12639 pubmed publisher
Chan J, Lapara K, Yee D. Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells. Oncogene. 2016;35:4235-43 pubmed publisher
Graewe S, Rankin K, Lehmann C, Deschermeier C, Hecht L, Froehlke U, et al. Hostile takeover by Plasmodium: reorganization of parasite and host cell membranes during liver stage egress. PLoS Pathog. 2011;7:e1002224 pubmed publisher
Ramos R, Swanson A, Bass J. Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2007;104:10470-5 pubmed
product information
Catalog Number :
22286
Product Name :
hIR-GFP
article :
doi10.1073/pnas.0701114104
id2906
pubmed_id17563366
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-N2
backbone_mutation
backbone_originClontech
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
IR
cloning
clone_methodRestriction Enzyme
cloning_site_3ApaI
cloning_site_5NheI
promoter
sequencing_primer_3TCG CCG GAC ACG CTG AAC TTG TG
sequencing_primer_5ACG CAA ATG GGC GGT AGG CG
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesCD220, HHF5
geneINSR
id3643
genbank_ids
M10051
mutation
nameINSR insulin receptor
shRNA_sequence
size4700
species
9606
Homo sapiens
tags
locationC terminal on insert
tagGFP
resistance markers :
800
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA