This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV Flag WT-PTEN
catalog :
22231
citations: 10
Reference
Garrido J, Alcantara K, Danac J, Serrano F, Cutiongco de la Paz E, Garcia R. The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene. Cells. 2021;10: pubmed publisher
Wani A, Gupta M, Ahmad M, Shah A, Ahsan A, Qazi P, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019;:1-19 pubmed publisher
Nan H, Han L, Ma J, Yang C, Su R, He J. STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1684-1692 pubmed publisher
Noguchi K, Dalton A, Howley B, McCall B, Yoshida A, Diehl J, et al. Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS ONE. 2017;12:e0177830 pubmed publisher
Altınoğlu S, Wang M, Li K, Li Y, Xu Q. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. Biomater Sci. 2016;4:1773-1780 pubmed
Lee S, Park J, Byun J, Jhun J, Jung K, Seo H, et al. PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs. Sci Rep. 2016;6:34617 pubmed publisher
González Sánchez A, Jaraíz Rodríguez M, Domínguez Prieto M, Herrero González S, Medina J, Tabernero A. Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes. Oncotarget. 2016;7:49819-49833 pubmed publisher
Kim J, Ku B, Woo T, Oh A, Jung Y, Soh Y, et al. Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain. Cell Death Dis. 2015;6:e1804 pubmed publisher
Beckham T, Cheng J, Lu P, Marrison S, Norris J, Liu X. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS ONE. 2013;8:e76593 pubmed publisher
Mosessian S, Avliyakulov N, Mulholland D, Boontheung P, Loo J, Wu H. Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex. J Biol Chem. 2009;284:30159-66 pubmed publisher
product information
Catalog Number :
22231
Product Name :
pCMV Flag WT-PTEN
article :
doi10.1074/jbc.M109.027995
id2897
pubmed_id19740742
bacterial resistance :
Kanamycin
cloning :
backbonepCMV-Tag2
backbone_mutation
backbone_originStratagene
backbone_size4300
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoR1
cloning_site_5BamH1
promoter
sequencing_primer_3T7
sequencing_primer_5T3
site_3_destroyed
site_5_destroyed
entrez_gene
aliases10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
genePTEN
id5728
genbank_ids
mutation
namePTEN
shRNA_sequence
size1209
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFlag
resistance markers :
640
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA