This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV4 p50
catalog :
21965
citations: 18
Reference
Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, et al. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Int J Biol Sci. 2022;18:4869-4883 pubmed publisher
Zhou Y, Shen H, Wu Y, Zhao X, Pei J, Mou Z, et al. Platelet-Rich Plasma Therapy Enhances the Beneficial Effect of Bone Marrow Stem Cell Transplant on Endometrial Regeneration. Front Cell Dev Biol. 2020;8:52 pubmed publisher
Mao G, Smyth S, Morris A. Regulation of PLPP3 gene expression by NF-κB family transcription factors. J Biol Chem. 2019;294:14009-14019 pubmed publisher
Kim G, Kwon H, Lee C, Verma R, Rudra D, Kim T, et al. Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness. Oncogenesis. 2018;7:91 pubmed publisher
Kojima Y, Volkmer J, McKenna K, Civelek M, Lusis A, Miller C, et al. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016;536:86-90 pubmed
de Andres M, Takahashi A, Oreffo R. Demethylation of an NF-?B enhancer element orchestrates iNOS induction in osteoarthritis and is associated with altered chondrocyte cell cycle. Osteoarthritis Cartilage. 2016;24:1951-1960 pubmed publisher
Zhang K, Wong P, Salvaggio C, Salhi A, Osman I, Bedogni B. Synchronized Targeting of Notch and ERBB Signaling Suppresses Melanoma Tumor Growth through Inhibition of Notch1 and ERBB3. J Invest Dermatol. 2016;136:464-472 pubmed publisher
Balasubramaniyan N, Ananthanarayanan M, Suchy F. Nuclear factor-?B regulates the expression of multiple genes encoding liver transport proteins. Am J Physiol Gastrointest Liver Physiol. 2016;310:G618-28 pubmed publisher
Huang H, Joseph L, Gurin M, Thorp E, Morrow J. Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription. J Mol Cell Cardiol. 2014;75:58-63 pubmed publisher
Boyd M, Coskun M, Lilje B, Andersson R, Hoof I, Bornholdt J, et al. Identification of TNF-?-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2. DNA Res. 2014;21:569-83 pubmed publisher
Hong J, Li D, Wands J, Souza R, Cao W. Role of NADPH oxidase NOX5-S, NF-?B, and DNMT1 in acid-induced p16 hypermethylation in Barrett's cells. Am J Physiol Cell Physiol. 2013;305:C1069-79 pubmed publisher
Zhou X, Li D, Resnick M, Wands J, Cao W. NADPH oxidase NOX5-S and nuclear factor ?B1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells. Mol Pharmacol. 2013;83:978-90 pubmed publisher
Teng Y, Chuang P, Liu Y. Nuclear factor-?B (NF-?B) regulates the expression of human testis-enriched Leucine-rich repeats and WD repeat domain containing 1 (LRWD1) gene. Int J Mol Sci. 2012;14:625-39 pubmed publisher
de Andrés M, Imagawa K, Hashimoto K, Gonzalez A, Roach H, Goldring M, et al. Loss of methylation in CpG sites in the NF-?B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum. 2013;65:732-42 pubmed publisher
Malátková P, Ebert B, Wsol V, Maser E. Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli. Biochem Biophys Res Commun. 2012;420:368-73 pubmed publisher
Luo H, Rankin G, Juliano N, Jiang B, Chen Y. Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Food Chem. 2012;130:321-328 pubmed
Schuhmann K, Pfaller C, Conzelmann K. The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity. J Virol. 2011;85:3162-71 pubmed publisher
Ballard D, Dixon E, Peffer N, Bogerd H, Doerre S, Stein B, et al. The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc Natl Acad Sci U S A. 1992;89:1875-9 pubmed
product information
Catalog Number :
21965
Product Name :
pCMV4 p50
article :
doi10.1073/pnas.89.5.1875
id2813
pubmed_id1542686
bacterial resistance :
Ampicillin
cloning :
backbonepCMV4
backbone_mutation
backbone_originAndersson,S. et al, J. Biol. Chem. 264 (14), 8222-8229 (1989)
backbone_size4874
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
NFKB1
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5HindIII
promoter
sequencing_primer_3hGH-rev
sequencing_primer_5CMV-F
site_3_destroyed1
site_5_destroyed
entrez_gene
aliasesCVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NF-kappabeta, NFKB-p105, NFKB-p50, NFkappaB
geneNFKB1
id4790
genbank_ids
M55643
mutation
nameNF-kB p50 subunit
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
resistance markers :
176
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA