This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
eIF2a 2
catalog :
21808
citations: 8
Reference
Wolzak K, Nölle A, Farina M, Abbink T, van der Knaap M, Verhage M, et al. Neuron-specific translational control shift ensures proteostatic resilience during ER stress. EMBO J. 2022;:e110501 pubmed publisher
Bai X, Ni J, Beretov J, Wasinger V, Wang S, Zhu Y, et al. Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis. Redox Biol. 2021;43:101993 pubmed publisher
Guo Q, Zhang Y, Zhang S, Jin J, Pang S, Wu X, et al. Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165649 pubmed publisher
Wei Y, Meng M, Tian Z, Xie F, Yin Q, Dai C, et al. Pharmacological preconditioning with the cellular stress inducer thapsigargin protects against experimental sepsis. Pharmacol Res. 2019;141:114-122 pubmed publisher
Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher
Chen H, Song R, Wang G, Ding Z, Yang C, Zhang J, et al. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. Sci Rep. 2015;5:13241 pubmed publisher
West N, Garcia Vargas A, Chalfant C, Park M. OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2. BMC Cancer. 2013;13:256 pubmed publisher
Kloft N, Neukirch C, von Hoven G, Bobkiewicz W, Weis S, Boller K, et al. A subunit of eukaryotic translation initiation factor 2?-phosphatase (CreP/PPP1R15B) regulates membrane traffic. J Biol Chem. 2012;287:35299-317 pubmed publisher
product information
Catalog Number :
21808
Product Name :
eIF2a 2
article :
doi
id2763
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA.CD2
backbone_mutation
backbone_originAddgene plasmid 21810
backbone_size5832
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Addgene sequencing results show small insertion in the MCS, upstream of EcoRI site. ORF is not affected. This insert is one of a few discrepancies between Addgene's quality control sequence and the sequence provided by the Ron lab. These discrepancies should not affect the function of the plasmid, but they have changed some of the restriction sites in the MCS. Please proceed cautiously when doing diagnostic digests or subcloning.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5HindIII
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesEIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
geneEIF2S1
id1965
genbank_ids
mutationS52A
nameeIF2a
shRNA_sequence
size1683
species
9606
Homo sapiens
tags
resistance markers :
421
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA