This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5 FLAG DEPTOR (PDZ domain)
catalog :
21701
citations: 5
Reference
Csukasi F, Bosakova M, Bárta T, Martin J, Arcedo J, Barad M, et al. Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Front Cell Dev Biol. 2022;10:963389 pubmed publisher
Li K, Yang P, Zhang Y, Zhang Y, Cao H, Liu P, et al. DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes. J Bone Miner Res. 2020;: pubmed publisher
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
González Terán B, López J, Rodríguez E, Leiva L, Martínez Martínez S, Bernal J, et al. p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun. 2016;7:10477 pubmed publisher
Peterson T, Laplante M, Thoreen C, Sancak Y, Kang S, Kuehl W, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009;137:873-86 pubmed publisher
product information
Catalog Number :
21701
Product Name :
pRK5 FLAG DEPTOR (PDZ domain)
article :
doi10.1016/j.cell.2009.03.046
id2654
pubmed_id19446321
bacterial resistance :
Ampicillin
cloning :
backbonepRK5-FLAG
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
DEPDC6
DEPTOR
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5SalI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesDEP.6, DEPDC6
geneDEPTOR
id64798
genbank_ids
NM_022783
mutationPDZ domain only
nameDEPTOR PDZ domain
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
432
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA