This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pTOPO-MCL1
catalog :
21605
citations: 15
Reference
Wang Y, Poon R. MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms. Cell Death Differ. 2022;: pubmed publisher
Wang X, Wei X, Cao Y, Xing P. Mcl-1 inhibition overcomes BET inhibitor resistance induced by low FBW7 expression in breast cancer. J Cell Mol Med. 2022;26:1672-1683 pubmed publisher
Sena E, Bou Rouphael J, Rocques N, Carron Homo C, Durand B. Mcl1 protein levels and Caspase-7 executioner protease control axial organizer cells survival. Dev Dyn. 2020;249:847-866 pubmed publisher
Noor A, Umelo I, Kronenberger P, Giron P, De Vlieghere E, De Wever O, et al. Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer. Oncotarget. 2018;9:28731-28744 pubmed publisher
Högstrand K, Darmanin S, Forshell T, Grandien A. Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. Oncotarget. 2018;9:21396-21410 pubmed publisher
Zhang C, Li Y, Weng X, Li L, Zhou M, Zhang D, et al. Nedaplatin enhanced apoptotic effects of ABT-737 in human cancer cells via Mcl-1 inhibition. Oncol Lett. 2016;12:4195-4202 pubmed
Park S, Lee D, Kim J, Kim B, Na Y, Jo M, et al. Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget. 2016;7:59503-59518 pubmed publisher
Li Y, Pan Y, Wu W, Mao S, Sun J, Zhao Y, et al. Evodiamine induces apoptosis and enhances apoptotic effects of erlotinib in wild-type EGFR NSCLC cells via S6K1-mediated Mcl-1 inhibition. Med Oncol. 2016;33:16 pubmed publisher
Mattoo A, Zhang J, Espinoza L, Jessup J. Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer cells and enhances the therapeutic efficacy of BH3 mimetics. Clin Cancer Res. 2014;20:5446-55 pubmed publisher
Eichhorn J, Sakurikar N, Alford S, Chu R, Chambers T. Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death. Cell Death Dis. 2013;4:e834 pubmed publisher
Zhang C, Zhou S, Li X, Wang B, Lin N, Feng L, et al. Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo. Oncol Rep. 2013;29:2275-82 pubmed publisher
Hosseini A, Espona Fiedler M, Soto Cerrato V, Quesada R, Pérez Tomás R, Guallar V. Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family members. PLoS ONE. 2013;8:e57562 pubmed publisher
Lamers F, Schild L, den Hartog I, Ebus M, Westerhout E, Ora I, et al. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. Eur J Cancer. 2012;48:3093-103 pubmed publisher
Zheng L, Yang W, Zhang C, Ding W, Zhu H, Lin N, et al. GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1. Cancer Lett. 2011;309:27-36 pubmed publisher
Maurer U, Charvet C, Wagman A, Dejardin E, Green D. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749-60 pubmed
product information
Catalog Number :
21605
Product Name :
pTOPO-MCL1
article :
doi10.1016/j.molcel.2006.02.009
id2704
pubmed_id16543145
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1 /V5-His-TOPO
backbone_mutation
backbone_originInvitrogen
backbone_size5523
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
BCL2L3
cloning
clone_methodTOPO Cloning
cloning_site_3T/A
cloning_site_5T/A
promoter
sequencing_primer_3BGH reverse
sequencing_primer_5T7
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesBCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
geneMCL1
id4170
genbank_ids
NM_021960
mutationInsert ends with a STOP codon, no V5-His-tag.
nameMCL-1
shRNA_sequence
size1052
species
9606
Homo sapiens
tags
resistance markers :
318
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA