This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
PKC alpha DN
catalog :
21235
citations: 15
Reference
Wang W, Prokopec J, Zhang Y, Sukhoplyasova M, Shinglot H, Wang M, et al. Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis. Dev Cell. 2022;57:228-245.e6 pubmed publisher
Liu Z, Wei Y, Zhang L, Yee P, Johnson M, Zhang X, et al. Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ. Oncogene. 2019;38:120-139 pubmed publisher
Cheng Y, Zhu Y, Xu W, Xu J, Yang M, Chen P, et al. PKCα in colon cancer cells promotes M1 macrophage polarization via MKK3/6-P38 MAPK pathway. Mol Carcinog. 2018;57:1017-1029 pubmed publisher
Sepp M, Vihma H, Nurm K, Urb M, Page S, Roots K, et al. The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A. J Neurosci. 2017;37:10516-10527 pubmed publisher
Kunde S, Rademacher N, Zieger H, Shoichet S. Protein kinase C regulates AMPA receptor auxiliary protein Shisa9/CKAMP44 through interactions with neuronal scaffold PICK1. FEBS Open Bio. 2017;7:1234-1245 pubmed publisher
Gonzalez A, Salinas Parra N, Leach D, Navar L, Prieto M. PGE2 upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells. Am J Physiol Renal Physiol. 2017;313:F1038-F1049 pubmed publisher
Bhalla M, Law D, Dowd G, Ireton K. Host Serine/Threonine Kinases mTOR and Protein Kinase C-? Promote InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2017;85: pubmed publisher
Vang A, Clements R, Chichger H, Kue N, Allawzi A, O Connell K, et al. Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2017;312:L748-L759 pubmed publisher
Sinnen B, Bowen A, Forte J, Hiester B, Crosby K, Gibson E, et al. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017;93:646-660.e5 pubmed publisher
Rath S, Anand A, Ghosh N, Das L, Kokate S, Dixit P, et al. Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell. Biochem Biophys Res Commun. 2016;471:205-12 pubmed publisher
Gonzalez A, Liu L, Lara L, Bourgeois C, Ibaceta Gonzalez C, Salinas Parra N, et al. PKC-α-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin II stimulation of renin in the collecting duct. Am J Physiol Renal Physiol. 2015;309:F880-8 pubmed publisher
Poli A, Ramazzotti G, Matteucci A, Manzoli L, Lonetti A, Suh P, et al. A novel DAG-dependent mechanism links PKCÉ‘ and Cyclin B1 regulating cell cycle progression. Oncotarget. 2014;5:11526-40 pubmed
Benseddik K, Sen Nkwe N, Daou P, Verdier Pinard P, Badache A. ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways. PLoS ONE. 2013;8:e55211 pubmed publisher
Chen X, Zhao X, Abeyweera T, Rotenberg S. Analysis of substrates of protein kinase C isoforms in human breast cells by the traceable kinase method. Biochemistry. 2012;51:7087-97 pubmed
Soh J, Weinstein I. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem. 2003;278:34709-16 pubmed
product information
Catalog Number :
21235
Product Name :
PKC alpha DN
article :
doi10.1074/jbc.M302016200
id1812
pubmed_id12794082
bacterial resistance :
Ampicillin
cloning :
backbonepHACE
backbone_mutation
backbone_origin
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
protein kinase C, alpha
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5EcoRI
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA
genePRKCA
id5578
genbank_ids
mutationK368R
namePKC alpha
shRNA_sequence
size2013
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagHA
resistance markers :
569
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA