This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
PKC alpha WT
catalog :
21232
citations: 14
Reference
Jin Y, Wu X, Shi B, Zhang Z, Guo X, Gan L, et al. Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. J Neurosci. 2019;39:9478-9490 pubmed publisher
Niemeyer A, Rinne A, Kienitz M. Receptor-specific regulation of atrial GIRK channel activity by different Ca2+-dependent PKC isoforms. Cell Signal. 2019;64:109418 pubmed publisher
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter J, et al. Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. J Biol Chem. 2019;294:887-901 pubmed publisher
Cheng Y, Zhu Y, Xu W, Xu J, Yang M, Chen P, et al. PKCα in colon cancer cells promotes M1 macrophage polarization via MKK3/6-P38 MAPK pathway. Mol Carcinog. 2018;57:1017-1029 pubmed publisher
Goode B, Mondal G, Hyun M, Ruiz D, Lin Y, Van Ziffle J, et al. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018;9:810 pubmed publisher
Kunde S, Rademacher N, Zieger H, Shoichet S. Protein kinase C regulates AMPA receptor auxiliary protein Shisa9/CKAMP44 through interactions with neuronal scaffold PICK1. FEBS Open Bio. 2017;7:1234-1245 pubmed publisher
Bhalla M, Law D, Dowd G, Ireton K. Host Serine/Threonine Kinases mTOR and Protein Kinase C-? Promote InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2017;85: pubmed publisher
Castanotto D, Lin M, Kowolik C, Koch T, Hansen B, Oerum H, et al. Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells. Mol Ther. 2016;24:1117-1125 pubmed publisher
Rath S, Anand A, Ghosh N, Das L, Kokate S, Dixit P, et al. Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell. Biochem Biophys Res Commun. 2016;471:205-12 pubmed publisher
Poli A, Ramazzotti G, Matteucci A, Manzoli L, Lonetti A, Suh P, et al. A novel DAG-dependent mechanism links PKCÉ‘ and Cyclin B1 regulating cell cycle progression. Oncotarget. 2014;5:11526-40 pubmed
Bailey T, Luan H, Tom E, Bielecki T, Mohapatra B, Ahmad G, et al. A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells. J Biol Chem. 2014;289:30443-58 pubmed publisher
Pan X, Kane L, Van Eyk J, Coulombe P. Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem. 2011;286:42403-13 pubmed publisher
Soh J, Weinstein I. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem. 2003;278:34709-16 pubmed
product information
Catalog Number :
21232
Product Name :
PKC alpha WT
article :
doi10.1074/jbc.M302016200
id1812
pubmed_id12794082
bacterial resistance :
Ampicillin
cloning :
backbonepHACE
backbone_mutation
backbone_origin
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
protein kinase C, alpha
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA
genePRKCA
id5578
genbank_ids
mutation
namePKC alpha
shRNA_sequence
size2019
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagHA
resistance markers :
569
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA