This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
MSCV-XZ066-EGFRvIII
catalog :
20737
citations: 14
Reference
Ramos A, Koch C, Liu Lupo Y, Hellinger R, Kyung T, Abbott K, et al. Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Nat Commun. 2023;14:8048 pubmed publisher
Lee S, Yeom S, Lee J, Park C. Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents. Sci Rep. 2021;11:10145 pubmed publisher
Gao M, Fu Y, Zhou W, Gui G, Lal B, Li Y, et al. EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma. Cancer Res. 2021;81:3580-3592 pubmed publisher
Fan F, Zhou M, Ye X, Mo Z, Ma Y, Luo L, et al. BEBT-109, a pan-mutant-selective EGFR inhibitor with potent antitumor activity in EGFR-mutant non-small cell lung cancer. Transl Oncol. 2021;14:100961 pubmed publisher
Hu L, Shen D, Liang D, Shi J, Song C, Jiang K, et al. Thyroid receptor-interacting protein 13 and EGFR form a feedforward loop promoting glioblastoma growth. Cancer Lett. 2020;493:156-166 pubmed publisher
Fraser J, Simpson J, Fontana R, Kishi Itakura C, Ktistakis N, Gammoh N. Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling. EMBO Rep. 2019;20:e47734 pubmed publisher
Zebertavage L, Bambina S, Shugart J, Alice A, Zens K, Lauer P, et al. A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity. PLoS ONE. 2019;14:e0209153 pubmed publisher
Kim D, Park S, Kim D, Jeong M, Noh J, Kwon Y, et al. Direct visualization of single-molecule membrane protein interactions in living cells. PLoS Biol. 2018;16:e2006660 pubmed publisher
Sirinian C, Papanastasiou A, Schizas M, Spella M, Stathopoulos G, Repanti M, et al. RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signaling. Oncogene. 2018;37:5101-5114 pubmed publisher
Papanastasiou A, Sirinian C, Plakoula E, Zolota V, Zarkadis I, Kalofonos H. RANK and EGFR in invasive breast carcinoma. Cancer Genet. 2017;216-217:61-66 pubmed publisher
Mayrhofer M, Gourain V, Reischl M, Affaticati P, Jenett A, Joly J, et al. A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Dis Model Mech. 2017;10:15-28 pubmed publisher
Ma Y, Tang N, Thompson R, Mobley B, Clark S, Sarkaria J, et al. InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. Clin Cancer Res. 2016;22:1767-76 pubmed publisher
Cross D, Ashton S, Ghiorghiu S, Eberlein C, Nebhan C, Spitzler P, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014;4:1046-61 pubmed publisher
Li L, Dutra A, Pak E, Labrie J, Gerstein R, Pandolfi P, et al. EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors. Neuro Oncol. 2009;11:9-21 pubmed publisher
product information
Catalog Number :
20737
Product Name :
MSCV-XZ066-EGFRvIII
article :
doi10.1215/15228517-2008-081
id2492
pubmed_id18812521
bacterial resistance :
Ampicillin
cloning :
backboneMSCV-XZ066
backbone_mutation
backbone_origin
backbone_size6256
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth notes :
Please note that Addgene's sequencing results identified potential polymorphisms L11F and C579Y in the EGFR sequence when compared to GenBank reference sequence NP_958439.1. The expressed protein functions as described in the associated publication.
origin :
37
pi :
alt_names
epidermal growth factor receptor vIII
cloning
clone_methodRestriction Enzyme
cloning_site_3XhoI
cloning_site_5XhoI
promoter
sequencing_primer_3
sequencing_primer_5MSCV
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
geneEGFR
id1956
genbank_ids
mutationEGFR with a 267 amino acid deletion in the extracellular domain (constitutively active)
nameEGFRvIII
shRNA_sequence
size
species
9606
Homo sapiens
tags
resistance markers :
425
tags :
Unknown
terms :
Other
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA