This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Luc-SIRT1 3'UTR
catalog :
20379
citations: 5
Reference
Baker J, Vuppusetty C, Colley T, Hassibi S, Fenwick P, Donnelly L, et al. MicroRNA-570 is a novel regulator of cellular senescence and inflammaging. FASEB J. 2018;:fj201800965R pubmed publisher
Baker J, Vuppusetty C, Colley T, Papaioannou A, Fenwick P, Donnelly L, et al. Oxidative stress dependent microRNA-34a activation via PI3K? reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep. 2016;6:35871 pubmed publisher
Kim H, Joe Y, Yu J, Chen Y, Jeong S, Mani N, et al. Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway. Biochim Biophys Acta. 2015;1852:1550-9 pubmed publisher
Ferreira D, Afonso M, Rodrigues P, Simão A, Pereira D, Borralho P, et al. c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. Mol Cell Biol. 2014;34:1100-20 pubmed publisher
Yamakuchi M, Ferlito M, Lowenstein C. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A. 2008;105:13421-6 pubmed publisher
product information
Catalog Number :
20379
Product Name :
Luc-SIRT1 3'UTR
article :
doi10.1073/pnas.0801613105
id2469
pubmed_id18755897
bacterial resistance :
Ampicillin
cloning :
backbonepMIR-REPORT
backbone_mutation
backbone_origin
backbone_size6470
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Luciferase
growth notes :
There are mismatches between Addgene's sequence and NCBI sequence for SIRT1 UTR. Deposit is aware of these changes and doesn't think they affect function.
origin :
37
pi :
alt_names
sirtuin (silent mating type information regulation 2 homolog) 1
cloning
clone_methodRestriction Enzyme
cloning_site_3SacI
cloning_site_5PmeI
promoter
sequencing_primer_3
sequencing_primer_5N/A
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesSIR2, SIR2L1, SIR2alpha
geneSIRT1
id23411
genbank_ids
mutation3'UTR of SIRT1
nameSIRT1
shRNA_sequence
size1420
species
9606
Homo sapiens
tags
resistance markers :
302
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA