This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5-HA GST RagC 120L
catalog :
19306
citations: 9
Reference
Malik N, Ferreira B, Hollstein P, Curtis S, Trefts E, Weiser Novak S, et al. Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Science. 2023;380:eabj5559 pubmed publisher
Akwa Y, Di Malta C, Zallo F, Gondard E, Lunati A, Diaz de Grenu L, et al. Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies. Autophagy. 2023;19:660-677 pubmed publisher
Hirst J, Hesketh G, Gingras A, Robinson M. Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. J Cell Biol. 2021;220: pubmed publisher
Wang M, Wang H, Tao Z, Xia Q, Hao Z, Prehn J, et al. C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis. Aging Cell. 2020;19:e13126 pubmed publisher
Jia J, Abudu Y, Claude Taupin A, Gu Y, Kumar S, Choi S, et al. Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell. 2018;70:120-135.e8 pubmed publisher
Khayati K, Antikainen H, Bonder E, Weber G, Kruger W, Jakubowski H, et al. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. FASEB J. 2017;31:598-609 pubmed publisher
Hong Brown L, Brown C, Kazi A, Navaratnarajah M, Lang C. Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am J Physiol Cell Physiol. 2012;302:C1557-65 pubmed publisher
Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, et al. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol. 2010;30:481-95 pubmed publisher
Sancak Y, Peterson T, Shaul Y, Lindquist R, Thoreen C, Bar Peled L, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008;320:1496-501 pubmed publisher
product information
Catalog Number :
19306
Product Name :
pRK5-HA GST RagC 120L
article :
doi10.1126/science.1157535
id2268
pubmed_id18497260
bacterial resistance :
Ampicillin
cloning :
backbonepRK5
backbone_mutation
backbone_originBD PharMingen
backbone_size4754
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
RRAGC
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5SalI
promoter
sequencing_primer_3pBABE 3'
sequencing_primer_5SP6, pGEX 5'
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesGTR2, RAGC, TIB929
geneRRAGC
id64121
genbank_ids
mutationQ120L
nameRas-related GTP binding C
shRNA_sequence
size1426
species
9606
Homo sapiens
tags
locationN terminal on insert
tagHA
locationN terminal on insert
tagGST
resistance markers :
432
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA