This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pGL2-Mcl-1
catalog :
19132
citations: 7
Reference
Jiang Y, Song L, Lin Y, Nowialis P, Gao Q, Li T, et al. ROS-mediated SRMS activation confers platinum resistance in ovarian cancer. Oncogene. 2023;42:1672-1684 pubmed publisher
Hino M, Iemura K, Ikeda M, Itoh G, Tanaka K. Chromosome alignment-maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl-1 expression. Cancer Sci. 2021;112:3711-3721 pubmed publisher
Xu J, Huang F, Yao Z, Jia C, Xiong Z, Liang H, et al. Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression. Cell Commun Signal. 2019;17:85 pubmed publisher
Haimovici A, Humbert M, Federzoni E, Shan Krauer D, Brunner T, Frese S, et al. PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression. Cell Death Differ. 2017;24:866-877 pubmed publisher
Liu H, Yang J, Yuan Y, Xia Z, Chen M, Xie L, et al. Regulation of Mcl-1 by constitutive activation of NF-κB contributes to cell viability in human esophageal squamous cell carcinoma cells. BMC Cancer. 2014;14:98 pubmed publisher
Ling X, Cao S, Cheng Q, Keefe J, Rustum Y, Li F. A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity. PLoS ONE. 2012;7:e45571 pubmed publisher
Ricci M, Kim S, Ogi K, Plastaras J, Ling J, Wang W, et al. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 2007;12:66-80 pubmed
product information
Catalog Number :
19132
Product Name :
pGL2-Mcl-1
article :
doi10.1016/j.ccr.2007.05.006
id2246
pubmed_id17613437
bacterial resistance :
Ampicillin
cloning :
backbonepGL2-basic
backbone_mutation
backbone_origin
backbone_size5597
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Luciferase
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3
sequencing_primer_5na
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
geneMCL1
id4170
genbank_ids
mutation
nameMcl-1 promoter
shRNA_sequence
size325
species
9606
Homo sapiens
tags
resistance markers :
129
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA