This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabepuro-myc-ER
catalog :
19128
citations: 14
Reference
Metz E, Wilder P, Popay T, Wang J, Liu Q, Kalluchi A, et al. Elevating SOX2 Downregulates MYC through a SOX2:MYC Signaling Axis and Induces a Slowly Cycling Proliferative State in Human Tumor Cells. Cancers (Basel). 2022;14: pubmed publisher
Scarpa M, Kapoor S, Tvedte E, Doshi K, Zou Y, Singh P, et al. Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication. Oncotarget. 2021;12:1763-1779 pubmed publisher
Akimov S, Jiang M, Kedaigle A, Arbez N, Marque L, Eddings C, et al. Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics. Hum Mol Genet. 2021;: pubmed publisher
Scarpa M, Singh P, Bailey C, Lee J, Kapoor S, Lapidus R, et al. PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3β-mediated c-Myc and Pim-1 proteasomal degradation. Mol Cancer Ther. 2021;: pubmed publisher
Lankes K, Hassan Z, Doffo M, Schneeweis C, Lier S, Ollinger R, et al. Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC. Mol Oncol. 2020;14:3048-3064 pubmed publisher
Pulikkan J, Hegde M, Ahmad H, Belaghzal H, Illendula A, Yu J, et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018;174:172-186.e21 pubmed publisher
Kurashima K, Sekimoto T, Oda T, Kawabata T, Hanaoka F, Yamashita T. Pol?, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress. J Cell Sci. 2018;131: pubmed publisher
Spehalski E, Capper K, Smith C, Morgan M, Dinkelmann M, Buis J, et al. MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress. Cancer Res. 2017;77:5327-5338 pubmed publisher
Maina P, Shao P, Liu Q, Fazli L, Tyler S, Nasir M, et al. c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer. Oncotarget. 2016;7:75585-75602 pubmed publisher
Han H, Chen Y, Cheng L, Prochownik E, Li Y. microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13. Oncotarget. 2016;7:16409-19 pubmed publisher
Akita H, Marquardt J, Durkin M, Kitade M, Seo D, Conner E, et al. MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism. Cancer Res. 2014;74:5903-13 pubmed publisher
Han H, Sun D, Li W, Shen H, Zhu Y, Li C, et al. A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis. Hepatology. 2013;57:2378-89 pubmed publisher
Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S. Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells. Mol Cell Biol. 2012;32:840-51 pubmed publisher
Ricci M, Jin Z, Dews M, Yu D, Thomas Tikhonenko A, Dicker D, et al. Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol. 2004;24:8541-55 pubmed
product information
Catalog Number :
19128
Product Name :
pBabepuro-myc-ER
article :
doi10.1128/MCB.24.19.8541-8555.2004
id1690
pubmed_id15367674
bacterial resistance :
Ampicillin
cloning :
backbonepBabepuro3:hbER tam
backbone_mutation
backbone_origin
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth notes :
Please see Littlewood et al., Nucleic Acids Res. 1995 May 25;23(10):1686-90 for more information regarding the mutant hormone binding domain of the mouse estrogen receptor (hbER Tam).
origin :
37
pi :
alt_names
cloning
clone_methodUnknown
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3pBABE-3
sequencing_primer_5pBABE-5
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMRTL, MYCC, bHLHe39, c-Myc
geneMYC
id4609
genbank_ids
mutation
namec-myc
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagmouse ER hormone binding domain
resistance markers :
129
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA