This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA-HIF1alpha P402A/P564A-pBabe-puro
catalog :
19005
citations: 14
Reference
Masgras I, Cannino G, Ciscato F, Sanchez Martin C, Darvishi F, Scantamburlo F, et al. Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3. Cell Death Differ. 2022;: pubmed publisher
Dizin E, Olivier V, Roth I, Sassi A, Arnoux G, Ramakrishnan S, et al. Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel-Mediated Sodium Transport in Collecting Duct Principal Cells. J Am Soc Nephrol. 2021;: pubmed publisher
Gao G, Zhao Y, Wang K, Wang F. Sodium-vitamin C-transporter-2 orchestrates lactate metabolism in mouse Sertoli cells. J Mol Endocrinol. 2020;: pubmed publisher
Shao S, Zhao L, An G, Zhang L, Jing X, Luo M, et al. Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer. FASEB J. 2020;: pubmed publisher
Zhang S, Zhang R, Xu R, Shang J, He H, Yang Q. MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3). Gene. 2020;733:144383 pubmed publisher
Wang M, Yan J, Cao X, Hua P, Li Z. Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1α activation. Biochem Pharmacol. 2020;172:113775 pubmed publisher
Kuang Y, Han X, Xu M, Yang Q. Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis. Cancer Med. 2018;7:1416-1429 pubmed publisher
Voss D, Spina R, Carter D, Lim K, Jeffery C, Bar E. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017;7:4292 pubmed publisher
Tosatto A, Sommaggio R, Kummerow C, Bentham R, Blacker T, Berecz T, et al. The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α. EMBO Mol Med. 2016;8:569-85 pubmed publisher
Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, et al. The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Nat Cell Biol. 2015;17:1523-35 pubmed publisher
Vindrieux D, Devailly G, Augert A, Le Calve B, Ferrand M, Pigny P, et al. Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget. 2014;5:1004-13 pubmed
Zhou W, Dosey T, Biechele T, Moon R, Horwitz M, Ruohola Baker H. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS ONE. 2011;6:e27460 pubmed publisher
Trisciuoglio D, Gabellini C, Desideri M, Ziparo E, Zupi G, Del Bufalo D. Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS ONE. 2010;5:e11772 pubmed publisher
Yan Q, Bartz S, Mao M, Li L, Kaelin W. The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Mol Cell Biol. 2007;27:2092-102 pubmed
product information
Catalog Number :
19005
Product Name :
HA-HIF1alpha P402A/P564A-pBabe-puro
article :
doi10.1128/MCB.01514-06
id2219
pubmed_id17220275
bacterial resistance :
Ampicillin
cloning :
backbonepBabe-puro
backbone_mutation
backbone_origin
backbone_size5188
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth temp :
DH5alpha
origin :
37
pi :
alt_names
HIF1a
cloning
clone_methodRestriction Enzyme
cloning_site_3Not I
cloning_site_5BamH I
promoter
sequencing_primer_3
sequencing_primer_5pBabe-5'
site_3_destroyed1
site_5_destroyed
entrez_gene
aliasesHIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
geneHIF1A
id3091
genbank_ids
NM_001530
mutationcDNA changed amino acids: Proline 402 to Alanine Proline 564 to Alanine
nameHypoxia inducible factor 1 alpha
shRNA_sequence
size2515
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagHA-tag
resistance markers :
238
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA