This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
ODD-Luciferase-pcDNA3
catalog :
18965
citations: 12
Reference
Ting K, Yu P, Dow R, Floro E, Ibrahim H, Scipione C, et al. Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway. J Immunol. 2023;211:1561-1577 pubmed publisher
Mukherjee A, Bezwada D, Greco F, Zandbergen M, Shen T, Chiang C, et al. Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis. Nat Metab. 2023;5:1563-1577 pubmed publisher
Kenny H, Hart P, Kordylewicz K, Lal M, Shen M, Kara B, et al. The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis. Cancers (Basel). 2021;13: pubmed publisher
Benej M, Wu J, Kreamer M, Kery M, Corrales Guerrero S, Papandreou I, et al. Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors. Cancers (Basel). 2021;13: pubmed publisher
Sulaiman A, McGarry S, Chambers J, Al Kadi E, Phan A, Li L, et al. Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells. Int J Mol Sci. 2020;21: pubmed publisher
von Spreckelsen N, Waldt N, Poetschke R, Kesseler C, Dohmen H, Jiao H, et al. KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020;8:41 pubmed publisher
Xiong G, Stewart R, Chen J, Gao T, Scott T, Samayoa L, et al. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. Nat Commun. 2018;9:4456 pubmed publisher
Cacace A, Sboarina M, Vazeille T, Sonveaux P. Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism. Oncogene. 2017;36:2074-2084 pubmed publisher
Miao H, Chen L, Hao L, Zhang X, Chen Y, Ruan Z, et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. Sci Rep. 2015;5:13092 pubmed publisher
Hou P, Kuo C, Cheng C, Liou J, Ann D, Chen Q. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. PLoS ONE. 2014;9:e113865 pubmed publisher
Gogate S, Fujita N, Skubutyte R, Shapiro I, Risbud M. Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1? degradation. J Bone Miner Res. 2012;27:1106-17 pubmed publisher
Safran M, Kim W, O Connell F, Flippin L, Gunzler V, Horner J, et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A. 2006;103:105-10 pubmed
product information
Catalog Number :
18965
Product Name :
ODD-Luciferase-pcDNA3
article :
doi10.1073/pnas.0509459103
id2224
pubmed_id16373502
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5352
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth temp :
DH5alpha
origin :
37
pi :
alt_names
HIF1a-ODD
cloning
clone_methodRestriction Enzyme
cloning_site_3Xba I
cloning_site_5Hind III
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesHIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
geneHIF1A
id3091
genbank_ids
AAA89082
mutationHIF1a ODD sequence fused in frame to luciferase ORF
nameODD-Firefly Luciferase
shRNA_sequence
size2047
species
9606
Homo sapiens
tags
resistance markers :
238
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA