This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA-HIF2alpha-pcDNA3
catalog :
18950
citations: 18
Reference
Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, et al. CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion. J Clin Invest. 2023;133: pubmed publisher
Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gyorffy B, Jalaguier S, et al. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53. Cell Mol Life Sci. 2022;79:270 pubmed publisher
Ivanova E, Sharma S, Brichkina A, Pfefferle P, Keber U, Pagenstecher A, et al. DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Biochem Biophys Res Commun. 2021;567:215-221 pubmed publisher
Riedl T, Faure Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, et al. HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence. Hepatology. 2021;: pubmed publisher
Kim H, Cho Y, Kim H, Kang D, Cheon D, Kim Y, et al. A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun. 2020;11:5023 pubmed publisher
Yu J, Shi X, Yang C, Bullova P, Hong C, Nesvick C, et al. A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycythemia. Aging (Albany NY). 2020;12:5781-5791 pubmed publisher
Yoo H, Park S, Nam M, Kang J, Kim K, Yeo J, et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Cell Metab. 2019;: pubmed publisher
Soyal S, Bonova P, Kwik M, Zara G, Auer S, Scharler C, et al. The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism. Mol Neurobiol. 2019;: pubmed publisher
Qi H, Wang S, Wu J, Yang S, Gray S, Ng C, et al. EGFR-AS1/HIF2A regulates the expression of FOXP3 to impact the cancer stemness of smoking-related non-small cell lung cancer. Ther Adv Med Oncol. 2019;11:1758835919855228 pubmed publisher
Faria M, Shepherd P, Pan Y, Chatterjee S, Navone N, Gustafsson J, et al. The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling. Oncotarget. 2018;9:36273-36288 pubmed publisher
Senavirathna L, Huang C, Yang X, Munteanu M, Sathiaseelan R, Xu D, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018;8:2709 pubmed publisher
Diaz Trelles R, Scimia M, Bushway P, Tran D, Monosov A, Monosov E, et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016;7:12088 pubmed publisher
Zhuang Z, Yang C, Ryska A, Ji Y, Hou Y, Graybill S, et al. HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma. Endocr Relat Cancer. 2016;23:L13-6 pubmed publisher
Imagawa K, de Andrés M, Hashimoto K, Itoi E, Otero M, Roach H, et al. Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis Rheumatol. 2014;66:3040-51 pubmed publisher
Zhu J, Jiang X, Chehab F. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2? at the CYP51 promoter. J Lipid Res. 2014;55:431-42 pubmed publisher
Guan Z, Ding C, Du Y, Zhang K, Zhu J, Zhang T, et al. HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells. Int J Oncol. 2014;44:393-402 pubmed publisher
Yang C, Sun M, Matro J, Huynh T, Rahimpour S, Prchal J, et al. Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas. Blood. 2013;121:2563-6 pubmed publisher
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin W. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 2002;1:237-46 pubmed
product information
Catalog Number :
18950
Product Name :
HA-HIF2alpha-pcDNA3
article :
doi10.1016/S1535-6108(02)00043-0
id2216
pubmed_id12086860
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5433
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth temp :
DH5alpha
origin :
37
pi :
alt_names
HIF2a
EPAS1
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoR I
cloning_site_5BamH I
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed1
site_5_destroyed
entrez_gene
aliasesECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
geneEPAS1
id2034
genbank_ids
HSU81984
mutationwt cDNA
nameHypoxia inducible factor 2 alpha
shRNA_sequence
size2637
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagHA-tag
resistance markers :
238
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA