This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
myc-mTOR
catalog :
1861
citations: 21
Reference
Teran O, Zanotelli M, Lin M, Cerione R, Wilson K. Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells. bioRxiv. 2023;: pubmed publisher
Kar A, Lee S, Sahoo P, Thames E, Yoo S, Houle J, et al. MicroRNAs 21 and 199a-3p Regulate Axon Growth Potential through Modulation of Pten and mTor mRNAs. Eneuro. 2021;8: pubmed publisher
Tooley A, Kazyken D, Bodur C, Gonzalez I, Fingar D. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem. 2021;297:100942 pubmed publisher
Majeed S, Batool A, Majeed R, Bhat N, Zargar M, Andrabi K. mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Cell Cycle. 2021;20:839-854 pubmed publisher
Zhang Y, Thery F, Wu N, Luhmann E, Dussurget O, Foecke M, et al. The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nat Commun. 2019;10:5383 pubmed publisher
Jung J, Macalino S, Cui M, Kim J, Kim H, Song D, et al. Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Cell Metab. 2019;29:1306-1319.e7 pubmed publisher
Li T, Han J, Jia L, Hu X, Chen L, Wang Y. PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation. Protein Cell. 2019;: pubmed publisher
Vargas J, Wang C, Bunker E, Hao L, Maric D, Schiavo G, et al. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy. Mol Cell. 2019;74:347-362.e6 pubmed publisher
Gleason C, Oses Prieto J, Li K, Saha B, Situ G, Burlingame A, et al. Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. J Cell Sci. 2019;132: pubmed publisher
Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, et al. The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex. Cell Metab. 2019;29:653-667.e6 pubmed publisher
Oka S, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, et al. Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes. J Biol Chem. 2017;292:18988-19000 pubmed publisher
Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, et al. Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase. Biochim Biophys Acta Mol Cell Res. 2017;1864:749-759 pubmed publisher
Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al. Regulation of mTORC1 by lysosomal calcium and calmodulin. elife. 2016;5: pubmed publisher
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
González Terán B, López J, Rodríguez E, Leiva L, Martínez Martínez S, Bernal J, et al. p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Nat Commun. 2016;7:10477 pubmed publisher
Lipner M, Marayati R, Deng Y, Wang X, Raftery L, O Neil B, et al. Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts. PLoS ONE. 2016;11:e0147113 pubmed publisher
Ghosh A, Marshall C, Coric T, Shim E, Kirkman R, Ballestas M, et al. Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. Oncotarget. 2015;6:17895-910 pubmed
Xie J, Ponuwei G, Moore C, Willars G, Tee A, Herbert T. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Cell Signal. 2011;23:1927-35 pubmed publisher
Qin Y, Yao L, King E, Buddavarapu K, Lenci R, Chocron E, et al. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010;42:229-33 pubmed publisher
Sarbassov D, Ali S, Kim D, Guertin D, Latek R, Erdjument Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004;14:1296-302 pubmed
product information
Catalog Number :
1861
Product Name :
myc-mTOR
article :
doi10.1016/j.cub.2004.06.054
id129
pubmed_id15268862
bacterial resistance :
Ampicillin
cloning :
backbonepRK5
backbone_mutation
backbone_originBD Pharmingen
backbone_size4754
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
RAFT1
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5ClaI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesFrap1, RAFT1
geneMtor
id56718
genbank_ids
mutation
namemTOR
shRNA_sequence
size
species
10116
Rattus norvegicus
tags
locationN terminal on backbone
tagMyc
resistance markers :
432
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA