This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Flag-Bcl2
catalog :
18003
citations: 19
Reference
Kumari A, Gesumaria L, Liu Y, Hughitt V, Zhang X, Ceribelli M, et al. mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer. JCI Insight. 2023;8: pubmed publisher
Dulloo I, Atakpa Adaji P, Yeh Y, Levet C, Muliyil S, Lu F, et al. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat Commun. 2022;13:1257 pubmed publisher
Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, et al. Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021;12:6896 pubmed publisher
Son J, Kim M, Lee J, Kim J, Chun E, Lee K. Hepatitis B virus X Protein Promotes Liver Cancer Progression through Autophagy Induction in Response to TLR4 Stimulation. Immune Netw. 2021;21:e37 pubmed publisher
Shiiba I, Takeda K, Nagashima S, Ito N, Tokuyama T, Yamashita S, et al. MITOL promotes cell survival by degrading Parkin during mitophagy. EMBO Rep. 2021;:e49097 pubmed publisher
He Y, Zhang X, Chang J, Kim H, Zhang P, Wang Y, et al. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nat Commun. 2020;11:1996 pubmed publisher
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019;25:1938-1947 pubmed publisher
Field J, Martens M, Mughal W, Hai Y, Chapman D, Hatch G, et al. Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress. Cell Death Discov. 2018;4:37 pubmed publisher
Talukdar S, Pradhan A, Bhoopathi P, Shen X, August L, Windle J, et al. MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A. 2018;115:5768-5773 pubmed publisher
Chen M, Wu D, Wang G, Wang Y, Chen C, Lee H. MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2. Oncotarget. 2018;9:13758-13767 pubmed publisher
Oing C, Tennstedt P, Simon R, Volquardsen J, Borgmann K, Bokemeyer C, et al. BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy. Cancer Lett. 2018;423:60-70 pubmed publisher
Mughal W, Martens M, Field J, Chapman D, Huang J, Rattan S, et al. Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition. Cell Death Differ. 2018;25:1732-1748 pubmed publisher
Wu D, Wang Y, Wang L, Chen C, Lee H. A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop. Theranostics. 2018;8:1256-1269 pubmed publisher
Huang Z, Fang W, Liu W, Wang L, Liu B, Liu S, et al. Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell. Eur J Pharmacol. 2018;823:58-64 pubmed publisher
Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong C, et al. Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy. 2016;12:1340-54 pubmed publisher
Rui Y, Xu Z, Chen Z, Zhang S. The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Autophagy. 2015;11:812-32 pubmed publisher
Ren S, Shen J, Cheng A, Lu L, Chan R, Li Z, et al. FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS ONE. 2013;8:e63641 pubmed publisher
Fei B, Yu S, Geahlen R. Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Biochim Biophys Acta. 2013;1833:2153-64 pubmed publisher
Wang N, Unkila M, Reineks E, Distelhorst C. Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death. J Biol Chem. 2001;276:44117-28 pubmed
product information
Catalog Number :
18003
Product Name :
Flag-Bcl2
article :
doi10.1074/jbc.M101958200
id2100
pubmed_id11546793
bacterial resistance :
Kanamycin
cloning :
backbonepCMV-Tag2B
backbone_mutation
backbone_originStratagene
backbone_size4300
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
Bcl2
cloning
clone_methodRestriction Enzyme
cloning_site_3unknown
cloning_site_5unknown
promoter
sequencing_primer_3T7
sequencing_primer_5T3
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBcl-2, PPP1R50
geneBCL2
id596
genbank_ids
mutation
nameBcl-2
shRNA_sequence
size720
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFlag
plasmid copy :
PCR amplified Bcl-2 from pB4 plasmid purchased from ATCC
resistance markers :
117
tags :
Unknown
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA