This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Flag-SIRT1 H363Y
catalog :
1792
citations: 11
Reference
Yang Y, Zhang S, Guan J, Jiang Y, Zhang J, Luo L, et al. SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2022;1868:166365 pubmed publisher
Chen Y, Jiang Y, Yang Y, Huang X, Sun C. SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis. Neurotox Res. 2021;: pubmed publisher
Bayele H. A conserved mechanism of sirtuin signalling through steroid hormone receptors. Biosci Rep. 2019;39: pubmed publisher
Chen X, Huan H, Liu C, Luo Y, Shen J, Zhuo Y, et al. Deacetylation of β-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. Cancer Lett. 2019;463:1-10 pubmed publisher
Weston S, Matthews K, Lent R, Vlk A, Haupt R, Kingsbury T, et al. A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for MERS-CoV replication. J Virol. 2019;: pubmed publisher
Sabir M, Khan Z, Hu C, Galligan M, Dussik C, Mallick S, et al. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation. J Steroid Biochem Mol Biol. 2017;172:117-129 pubmed publisher
Singh P, Hanson P, Morris C. SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. BMC Neurosci. 2017;18:46 pubmed publisher
Das D, Smith N, Wang X, Morgan I. The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2. J Virol. 2017;91: pubmed publisher
Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski M, Biswas A, et al. Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Biochim Biophys Acta. 2016;1859:1155-1169 pubmed publisher
Lee W, Lee W, Cheng C, Chen K, Chou C, Chung C, et al. Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget. 2015;6:27580-95 pubmed publisher
Brunet A, Sweeney L, Sturgill J, Chua K, Greer P, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004;303:2011-5 pubmed
product information
Catalog Number :
1792
Product Name :
Flag-SIRT1 H363Y
article :
doi10.1126/science.1094637
id108
pubmed_id14976264
bacterial resistance :
Ampicillin
cloning :
backbonepECE
backbone_mutation
backbone_origin
backbone_size2900
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
Sir2
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5HindIII
promoter
sequencing_primer_3SV40pA-R
sequencing_primer_5SV40pro-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesSIR2, SIR2L1, SIR2alpha
geneSIRT1
id23411
genbank_ids
mutationH363Y, deacetylase domain mutation
nameSIRT1
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on insert
tagFlag
resistance markers :
174
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA