This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCS2-MT GLI2 delta N
catalog :
17649
citations: 9
Reference
Hor xe1 k P, Kreisingerov xe1 K, R xe9 da J, Ondru x161 ov xe1 L, Balko J, x17d xe1 kov xe1 P, et al. The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cells. Oncol Rep. 2023;49: pubmed publisher
Luo J, Wang J, Yang J, Huang W, Liu J, Tan W, et al. Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway. J Nat Med. 2022;76:584-593 pubmed publisher
Kowolik C, Lin M, Xie J, Overman L, Horne D. Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer. J Exp Clin Cancer Res. 2019;38:431 pubmed publisher
Babu D, Fanelli A, Mellone S, Muniswamy R, Wasniewska M, Prodam F, et al. Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization. Clin Endocrinol (Oxf). 2018;: pubmed publisher
Han W, Jackson D, Matissek S, Misurelli J, Neil M, Sklavanitis B, et al. Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2. J Immunol. 2017;198:4481-4489 pubmed publisher
Vlčková K, Ondrušová L, Vachtenheim J, Réda J, Dundr P, Zadinová M, et al. Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Cell Death Dis. 2016;7:e2048 pubmed publisher
David A, Liu F, Tibelius A, Vulprecht J, Wald D, Rothermel U, et al. Lack of centrioles and primary cilia in STIL(-/-) mouse embryos. Cell Cycle. 2014;13:2859-68 pubmed publisher
Tang Y, Gholamin S, Schubert S, Willardson M, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014;20:732-40 pubmed publisher
Roessler E, Ermilov A, Grange D, Wang A, Grachtchouk M, Dlugosz A, et al. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet. 2005;14:2181-8 pubmed
product information
Catalog Number :
17649
Product Name :
pCS2-MT GLI2 delta N
article :
doi10.1093/hmg/ddi222
id2006
pubmed_id15994174
bacterial resistance :
Ampicillin
cloning :
backbonepCS2-MT
backbone_mutation
backbone_origin
backbone_size4350
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5EcoRI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCJS, HPE9, PHS2, THP1, THP2
geneGLI2
id2736
genbank_ids
mutationMissing 328 N-terminal amino acids
nameGLI2
shRNA_sequence
size3800
species
9606
Homo sapiens
tags
locationN terminal on backbone
tag6x Myc
resistance markers :
420
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA