This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5-HA-Parkin
catalog :
17613
citations: 17
Reference
Kapadia B, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus R. PARK2 regulates eIF4B-driven lymphomagenesis. Mol Cancer Res. 2022;: pubmed publisher
Esser L, Branchi V, Shakeri F, Simon A, Stephan C, Kristiansen G, et al. Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. Int J Oncol. 2022;60: pubmed publisher
Bu L, Wang H, Hou P, Guo S, He M, Xiao J, et al. The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5. Front Immunol. 2020;11:1926 pubmed publisher
Ryan T, Phillips E, Collier C, Jb Robinson A, Routledge D, Wood R, et al. Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles. EMBO J. 2020;39:e102539 pubmed publisher
Chen Q, Lei J, Bao J, Wang H, Hao W, Li L, et al. BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Adv Sci (Weinh). 2020;7:1903616 pubmed publisher
Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, et al. Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol. 2019;202:1428-1440 pubmed publisher
Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey M, et al. Miro proteins prime mitochondria for Parkin translocation and mitophagy. EMBO J. 2019;38: pubmed publisher
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed publisher
Lahuerta M, Aguado C, Sánchez Martín P, Sanz P, Knecht E. Degradation of altered mitochondria by autophagy is impaired in Lafora disease. FEBS J. 2018;285:2071-2090 pubmed publisher
Pascucci B, D Errico M, Romagnoli A, De Nuccio C, Savino M, Pietraforte D, et al. Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells. Oncotarget. 2017;8:102852-102867 pubmed publisher
Grimaldo L, Sandoval A, Garza López E, Felix R. Involvement of Parkin in the ubiquitin proteasome system-mediated degradation of N-type voltage-gated Ca2+ channels. PLoS ONE. 2017;12:e0185289 pubmed publisher
Hammerling B, Najor R, Cortez M, Shires S, Leon L, Gonzalez E, et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017;8:14050 pubmed publisher
Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
Sargsyan A, Cai J, Fandino L, Labasky M, Forostyan T, Colosimo L, et al. Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor. Sci Rep. 2015;5:12397 pubmed publisher
Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, et al. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015;11:547-59 pubmed publisher
Kim S, Syed G, Siddiqui A. Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 2013;9:e1003285 pubmed publisher
Zhang Y, Gao J, Chung K, Huang H, Dawson V, Dawson T. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A. 2000;97:13354-9 pubmed
product information
Catalog Number :
17613
Product Name :
pRK5-HA-Parkin
article :
doi10.1073/pnas.240347797
id162
pubmed_id11078524
bacterial resistance :
Ampicillin
cloning :
backbonepRK5-HA
backbone_mutation
backbone_origin
backbone_size4800
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5SalI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAR-JP, LPRS2, PARK2, PDJ
genePRKN
id5071
genbank_ids
mutation
nameParkin
shRNA_sequence
size1400
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagHA
resistance markers :
107
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA