This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5-Myc-Parkin
catalog :
17612
citations: 12
Reference
Botta S, de Prisco N, Chemiakine A, Brandt V, Cabaj M, Patel P, et al. Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms. EMBO J. 2023;42:e112721 pubmed publisher
Quiles J, Najor R, Gonzalez E, Jeung M, Liang W, Burbach S, et al. Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy. Sci Signal. 2023;16:eabo4457 pubmed publisher
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher
Franci L, Tubita A, Bertolino F, Palma A, Cannino G, Settembre C, et al. MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process. Aging Cell. 2022;:e13620 pubmed publisher
Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher
Kim S, Kim N, Park S, Jeon Y, Lee J, Yoo S, et al. Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Autophagy. 2019;:1-21 pubmed publisher
Zhu M, Cortese G, Waites C. Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol. 2018;16:100 pubmed publisher
Hammerling B, Shires S, Leon L, Cortez M, Gustafsson A. Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin. Small Gtpases. 2017;:1-8 pubmed publisher
Hammerling B, Najor R, Cortez M, Shires S, Leon L, Gonzalez E, et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017;8:14050 pubmed publisher
Birsa N, Norkett R, Wauer T, Mevissen T, Wu H, Foltynie T, et al. Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J Biol Chem. 2014;289:14569-82 pubmed publisher
Cui M, Tang X, Christian W, Yoon Y, Tieu K. Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem. 2010;285:11740-52 pubmed publisher
Zhang Y, Gao J, Chung K, Huang H, Dawson V, Dawson T. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A. 2000;97:13354-9 pubmed
product information
Catalog Number :
17612
Product Name :
pRK5-Myc-Parkin
article :
doi10.1073/pnas.240347797
id162
pubmed_id11078524
bacterial resistance :
Ampicillin
cloning :
backbonepRK5-Myc
backbone_mutation
backbone_origin
backbone_size4800
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5SalI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAR-JP, LPRS2, PARK2, PDJ
genePRKN
id5071
genbank_ids
mutation
nameParkin
shRNA_sequence
size1400
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagMyc
resistance markers :
107
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA