This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pMXs-hc-MYC
catalog :
17220
citations: 71
Reference
Palomino Lago E, Jelbert E, Baird A, Lam P, Guest D. Equine induced pluripotent stem cells are responsive to inflammatory cytokines before and after differentiation into musculoskeletal cell types. In Vitro Cell Dev Biol Anim. 2023;59:514-527 pubmed publisher
Son B, Yoon H, Ryu J, Lee H, Joo J, Park H, et al. Enhanced efficiency of generating human-induced pluripotent stem cells using Lin28-30Kc19 fusion protein. Front Bioeng Biotechnol. 2022;10:911614 pubmed publisher
von Joest M, Chen C, Douch xe9 T, Chantrel J, Chiche A, Gianetto Q, et al. Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming. Cell Rep. 2022;40:111074 pubmed publisher
Holoch D, Wassef M, Lövkvist C, Zielinski D, Aflaki S, Lombard B, et al. A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals. Nat Genet. 2021;53:1686-1697 pubmed publisher
Gao Y, Miles S, Dasgupta P, Rankin G, Cutler S, Chen Y. Trichodermin Induces G0/G1 Cell Cycle Arrest by Inhibiting c-Myc in Ovarian Cancer Cells and Tumor Xenograft-Bearing Mice. Int J Mol Sci. 2021;22: pubmed publisher
Setthawong P, Phakdeedindan P, Techakumphu M, Tharasanit T. Molecular signature and colony morphology affect in vitro pluripotency of porcine induced pluripotent stem cells. Reprod Domest Anim. 2021;56:1104-1116 pubmed publisher
Wang L, Zhao H, Wu J, Ren J, Luo H, Zuo X, et al. An induced pluripotent stem cell line (CSUi004-A) from skin fibroblasts of a healthy individual. Stem Cell Res. 2021;53:102336 pubmed publisher
Sanchez Vazquez R, Martinez P, Blasco M. AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet. 2021;17:e1009410 pubmed publisher
Wei H, Beeson G, Ye Z, Zhang J, Yao H, Damon B, et al. Activation of Wnt/β-catenin signalling and HIF1α stabilisation alters pluripotency and differentiation/proliferation properties of human-induced pluripotent stem cells. Biol Cell. 2020;: pubmed publisher
Kim K, Yoon J, Kim J, Röpke A, Shin B, Wook Han D, et al. Generation of a human iPSC line (MPIi007-A) from a patient with Metachromatic leukodystrophy. Stem Cell Res. 2020;48:101993 pubmed publisher
Kim K, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, et al. Reprogramming competence of OCT factors is determined by transactivation domains. Sci Adv. 2020;6: pubmed publisher
Kim K, Yoon J, Shin B, Röpke A, Han D, Scholer H. Generation of a human iPSC line (MPIi006-A) from a patient with Pelizaeus-Merzbacher disease. Stem Cell Res. 2020;46:101839 pubmed publisher
Glaß H, Neumann P, Pal A, Reinhardt P, Storch A, Sterneckert J, et al. Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis. Int J Mol Sci. 2020;21: pubmed publisher
Uysal B, Löffler H, Rosa F, Lerche H, Schwarz N. Generation of an induced pluripotent stem cell (iPSC) line (HIHDNEi003-A) from a patient with developmental and epileptic encephalopathy carrying a KCNA2 (p.Thr374Ala) mutation. Stem Cell Res. 2019;40:101543 pubmed publisher
Dutton L, Dudhia J, Guest D, Connolly D. Inducing Pluripotency in the Domestic Cat (Felis catus). Stem Cells Dev. 2019;28:1299-1309 pubmed publisher
Liu L, Li Y, Guo N, Li S, Ma X, Zhang Y, et al. Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation. Cell Rep. 2019;27:455-466.e5 pubmed publisher
Melnik S, Werth N, Boeuf S, Hahn E, Gotterbarm T, Anton M, et al. Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells. Stem Cell Res Ther. 2019;10:73 pubmed publisher
Setthawong P, Phakdeedindan P, Tiptanavattana N, Rungarunlert S, Techakumphu M, Tharasanit T. Generation of porcine induced-pluripotent stem cells from Sertoli cells. Theriogenology. 2019;127:32-40 pubmed publisher
Schwarz N, Uysal B, Rosa F, Löffler H, Mau Holzmann U, Liebau S, et al. Generation of an induced pluripotent stem cell (iPSC) line from a patient with developmental and epileptic encephalopathy carrying a KCNA2 (p.Leu328Val) mutation. Stem Cell Res. 2018;33:6-9 pubmed publisher
Pane L, Fulcoli F, Cirino A, Altomonte A, Ferrentino R, Bilio M, et al. Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Dis Model Mech. 2018;11: pubmed publisher
Phakdeedindan P, Setthawong P, Tiptanavattana N, Rungarunlert S, Ingrungruanglert P, Israsena N, et al. Rabbit induced pluripotent stem cells retain capability of in vitro cardiac differentiation. Exp Anim. 2019;68:35-47 pubmed publisher
Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, et al. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018;13:e0197046 pubmed publisher
Baird A, Lindsay T, Everett A, Iyemere V, Paterson Y, McClellan A, et al. Osteoblast differentiation of equine induced pluripotent stem cells. Biol Open. 2018;7: pubmed publisher
Thekkeparambil Chandrabose S, Sriram S, Subramanian S, Cheng S, Ong W, Rozen S, et al. Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. Stem Cell Res Ther. 2018;9:68 pubmed publisher
Salas S, Ng N, Gerami Naini B, Anchan R. Induced Pluripotent Stem Cells from Ovarian Tissue. Curr Protoc Hum Genet. 2017;95:21.10.1-21.10.22 pubmed publisher
Chakritbudsabong W, Sariya L, Pamonsupornvichit S, Pronarkngver R, Chaiwattanarungruengpaisan S, Ferreira J, et al. Generation of a pig induced pluripotent stem cell (piPSC) line from embryonic fibroblasts by incorporating LIN28 to the four transcriptional factor-mediated reprogramming: VSMUi001-D. Stem Cell Res. 2017;24:21-24 pubmed publisher
Bansho Y, Lee J, Nishida E, Nakajima Koyama M. Identification and characterization of secreted factors that are upregulated during somatic cell reprogramming. FEBS Lett. 2017;591:1584-1600 pubmed publisher
Verusingam N, Yeap S, Ky H, Paterson I, Khoo S, Cheong S, et al. Susceptibility of Human Oral Squamous Cell Carcinoma (OSCC) H103 and H376 cell lines to Retroviral OSKM mediated reprogramming. Peerj. 2017;5:e3174 pubmed publisher
Zhang L, Jambusaria A, Hong Z, Marsboom G, Toth P, Herbert B, et al. SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells. Circulation. 2017;135:2505-2523 pubmed publisher
Bharathan S, Manian K, Aalam S, Palani D, Deshpande P, Pratheesh M, et al. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biol Open. 2017;6:100-108 pubmed publisher
Zhu Z, Li C, Zeng Y, Ding J, Qu Z, Gu J, et al. PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs. Cell Stem Cell. 2017;20:274-289.e7 pubmed publisher
Rivera T, Haggblom C, Cosconati S, Karlseder J. A balance between elongation and trimming regulates telomere stability in stem cells. Nat Struct Mol Biol. 2017;24:30-39 pubmed publisher
Wassef M, Michaud A, Margueron R. Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors. Cell Cycle. 2016;15:2256-62 pubmed publisher
Zapata Linares N, Rodriguez S, Mazo M, Abizanda G, Andreu E, Barajas M, et al. Generation and characterization of human iPSC line generated from mesenchymal stem cells derived from adipose tissue. Stem Cell Res. 2016;16:20-3 pubmed publisher
Eid W, Abdel Rehim W. Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A. Biol Chem. 2016;397:1205-1213 pubmed publisher
Zukeran A, Takahashi A, Takaoka S, Mohamed H, Suzuki T, Ikematsu S, et al. The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells. Biochem Biophys Res Commun. 2016;474:233-239 pubmed publisher
Villa Diaz L, Kim J, Laperle A, Palecek S, Krebsbach P. Inhibition of Focal Adhesion Kinase Signaling by Integrin ?6?1 Supports Human Pluripotent Stem Cell Self-Renewal. Stem Cells. 2016;34:1753-64 pubmed publisher
Sancho Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, et al. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016;7:10743 pubmed publisher
Bhutani K, Nazor K, Williams R, Tran H, Dai H, Dzakula Z, et al. Whole-genome mutational burden analysis of three pluripotency induction methods. Nat Commun. 2016;7:10536 pubmed publisher
Ryu J, Park H, Park J, Lee H, Rhee W, Park T. Soluble expression and stability enhancement of transcription factors using 30Kc19 cell-penetrating protein. Appl Microbiol Biotechnol. 2016;100:3523-32 pubmed publisher
Qian X, Kim J, Tong W, Villa Diaz L, Krebsbach P. DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover. Stem Cells. 2016;34:588-600 pubmed publisher
Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, et al. Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker. PLoS ONE. 2015;10:e0138193 pubmed publisher
Boza Morán M, Martínez Hernández R, Bernal S, Wanisch K, Also Rallo E, Le Heron A, et al. Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons. Sci Rep. 2015;5:11696 pubmed publisher
Doerr J, Böckenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, et al. Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy. Mol Ther. 2015;23:1519-31 pubmed publisher
Fuerstenau Sharp M, Zimmermann M, Stark K, Jentsch N, Klingenstein M, Drzymalski M, et al. Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells. PLoS ONE. 2015;10:e0126596 pubmed publisher
Chuang C, Huang M, Chen H, Tseng L, Yu C, Stone L, et al. Granulosa cell-derived induced pluripotent stem cells exhibit pro-trophoblastic differentiation potential. Stem Cell Res Ther. 2015;6:14 pubmed publisher
Tatarishvili J, Oki K, Monni E, Koch P, Memanishvili T, Buga A, et al. Human induced pluripotent stem cells improve recovery in stroke-injured aged rats. Restor Neurol Neurosci. 2014;32:547-58 pubmed publisher
Hartfield E, Yamasaki Mann M, Ribeiro Fernandes H, Vowles J, James W, Cowley S, et al. Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE. 2014;9:e87388 pubmed publisher
Sagie S, Ellran E, Katzir H, Shaked R, Yehezkel S, Laevsky I, et al. Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome. Hum Mol Genet. 2014;23:3629-40 pubmed publisher
Zhang L, Pan Y, Qin G, Chen L, Chatterjee T, Weintraub N, et al. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle. 2014;13:762-71 pubmed publisher
Goh P, Caxaria S, Casper C, Rosales C, Warner T, Coffey P, et al. A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells. PLoS ONE. 2013;8:e81622 pubmed publisher
Mohsen Kanson T, Hafner A, Wdziekonski B, Takashima Y, Villageois P, Carrière A, et al. Differentiation of human induced pluripotent stem cells into brown and white adipocytes: role of Pax3. Stem Cells. 2014;32:1459-67 pubmed publisher
Outani H, Okada M, Yamashita A, Nakagawa K, Yoshikawa H, Tsumaki N. Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors. PLoS ONE. 2013;8:e77365 pubmed publisher
Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Höing S, et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE. 2013;8:e59252 pubmed publisher
Ruiz S, Gore A, Li Z, Panopoulos A, Montserrat N, Fung H, et al. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun. 2013;4:1382 pubmed publisher
Pirozhkova I, Barat A, Dmitriev P, Kim E, Robert T, Guégan J, et al. Differences in transcription patterns between induced pluripotent stem cells produced from the same germ layer are erased upon differentiation. PLoS ONE. 2013;8:e53033 pubmed publisher
Chan Y, Goke J, Lu X, Venkatesan N, Feng B, Su I, et al. A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells. 2013;31:682-92 pubmed publisher
Buccini S, Haider K, Ahmed R, Jiang S, Ashraf M. Cardiac progenitors derived from reprogrammed mesenchymal stem cells contribute to angiomyogenic repair of the infarcted heart. Basic Res Cardiol. 2012;107:301 pubmed publisher
Mahalingam D, Kong C, Lai J, Tay L, Yang H, Wang X. Reversal of aberrant cancer methylome and transcriptome upon direct reprogramming of lung cancer cells. Sci Rep. 2012;2:592 pubmed publisher
Frank S, Zhang M, Scholer H, Greber B. Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions. PLoS ONE. 2012;7:e41958 pubmed publisher
Mak S, Huang Y, Iranmanesh S, Vangipuram M, Sundararajan R, Nguyen L, et al. Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage. Stem Cells Int. 2012;2012:140427 pubmed publisher
Luo H, Rankin G, Juliano N, Jiang B, Chen Y. Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Food Chem. 2012;130:321-328 pubmed
Sugii S, Kida Y, Berggren W, Evans R. Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Nat Protoc. 2011;6:346-58 pubmed publisher
Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher
Ruiz S, Brennand K, Panopoulos A, Herrerias A, Gage F, Izpisua Belmonte J. High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS ONE. 2010;5:e15526 pubmed publisher
Spence J, Mayhew C, Rankin S, Kuhar M, Vallance J, Tolle K, et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011;470:105-9 pubmed publisher
Kamata M, Liu S, Liang M, Nagaoka Y, Chen I. Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter. Hum Gene Ther. 2010;21:1555-67 pubmed publisher
Hotta A, Cheung A, Farra N, Garcha K, Chang W, Pasceri P, et al. EOS lentiviral vector selection system for human induced pluripotent stem cells. Nat Protoc. 2009;4:1828-44 pubmed publisher
Moretti A, Bellin M, Jung C, Thies T, Takashima Y, Bernshausen A, et al. Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB J. 2010;24:700-11 pubmed publisher
Byrne J, Nguyen H, Reijo Pera R. Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts. PLoS ONE. 2009;4:e7118 pubmed publisher
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72 pubmed
product information
Catalog Number :
17220
Product Name :
pMXs-hc-MYC
article :
doi10.1016/j.cell.2007.11.019
id1893
pubmed_id18035408
bacterial resistance :
Ampicillin
cloning :
backbonepMXs
backbone_mutation
backbone_origin
backbone_size4600
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth notes :
The sequence of primer pMX-S1811 is GAC GGC ATC GCA GCT TGG ATA CAC.
growth strain :
Retroviral expression of human cMYC
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3attB2
cloning_site_5attB1
promoter
sequencing_primer_3
sequencing_primer_5pMX-S1811
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMRTL, MYCC, bHLHe39, c-Myc
geneMYC
id4609
genbank_ids
BAA01375.1
mutationNone
namec-MYC
shRNA_sequence
size1320
species
9606
Homo sapiens
tags
plasmid copy :
pMXs is from Dr. Toshio Kitamura of the University of Tokyo, the Institute of Medical Science. If you use this plasmid in a paper, please cite: Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp Hematol. 2003 Nov;31(11):1007-14. Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T, Kumagai H.
resistance markers :
596
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA