This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
human beta-catenin pcDNA3
catalog :
16828
citations: 42
Reference
Hunt B, Davis J, Fox L, Vicente Mu xf1 oz S, Lester C, Wells S, et al. RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. Oncogene. 2023;42:1716-1727 pubmed publisher
Sokolov D, Sharda N, Giri B, Hassan M, Singh D, Tarasiewicz A, et al. Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling. J Pineal Res. 2022;:e12808 pubmed publisher
Jiang L, Zhang S, An N, Chai G, Ye C. ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway. Int J Endocrinol. 2022;2022:5316102 pubmed publisher
Luo H, Zhu G, Eshelman M, Fung T, Lai Q, Wang F, et al. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Mol Cell. 2022;82:833-851.e11 pubmed publisher
Koujah L, Madavaraju K, Agelidis A, Patil C, Shukla D. Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection. MBio. 2021;12:e0279221 pubmed publisher
Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, et al. MiRNA-146a/AKT/β-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Front Oncol. 2021;11:651692 pubmed publisher
Tripathi S, Biswal B. SOX9 promotes epidermal growth factor receptor-tyrosine kinase inhibitor resistance via targeting β-catenin and epithelial to mesenchymal transition in lung cancer. Life Sci. 2021;277:119608 pubmed publisher
Alzofon N, Koc K, Panwell K, Pozdeyev N, Marshall C, Albuja Cruz M, et al. Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression. Mol Cancer Res. 2021;: pubmed publisher
Zhou S, Obianom O, Huang J, Guo D, Yang H, Li Q, et al. Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation. Pharmaceutics. 2021;13: pubmed publisher
Lepore Signorile M, Grossi V, Di Franco S, Forte G, Disciglio V, Fasano C, et al. Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids. Cell Death Dis. 2021;12:316 pubmed publisher
Baek D, Park K, Lee K, Jung S, Joung S, Kim J, et al. Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Cell Death Dis. 2021;12:238 pubmed publisher
Sorrenson B, Dissanayake W, Hu F, Lee K, Shepherd P. A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochem J. 2021;478:1605-1615 pubmed publisher
Ye Z, Gould T, Zhang H, Jin J, Weyand C, Goronzy J. The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a. NPJ Aging Mech Dis. 2021;7:4 pubmed publisher
Perfetto M, Xu X, Lu C, Shi Y, Yousaf N, Li J, et al. The RNA helicase DDX3 induces neural crest by promoting AKT activity. Development. 2021;148: pubmed publisher
Corbett D, Fabyan W, Grigoryan B, O Connor C, Johansson F, Batalov I, et al. Thermofluidic heat exchangers for actuation of transcription in artificial tissues. Sci Adv. 2020;6: pubmed publisher
Kim G, Fang X, Lim W, Park J, Kang T, Kim J, et al. Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1. Int J Mol Sci. 2020;21: pubmed publisher
Sikder M, Sivaprakasam S, Brown T, Thangaraju M, Bhutia Y, Ganapathy V. SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Biochem J. 2020;477:1409-1425 pubmed publisher
Sen B, Paradise C, Xie Z, Sankaran J, Uzer G, Styner M, et al. β-Catenin Preserves the Stem State of Murine Bone Marrow Stromal Cells Through Activation of EZH2. J Bone Miner Res. 2020;35:1149-1162 pubmed publisher
Maier J, Elmenofi S, Taschauer A, Anton M, Sami H, Ogris M. Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway. PLoS ONE. 2019;14:e0226570 pubmed publisher
Chen X, Huan H, Liu C, Luo Y, Shen J, Zhuo Y, et al. Deacetylation of β-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells. Cancer Lett. 2019;463:1-10 pubmed publisher
Nan J, Kim O, Lee M. β-Catenin expression is associated with cell invasiveness in pancreatic cancer. Korean J Intern Med. 2019;34:618-625 pubmed publisher
Wang J, Li Y, Gao L, Yan F, Gao G, Li L. GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells. Front Cell Neurosci. 2018;12:283 pubmed publisher
Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, et al. USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization. Cell Death Differ. 2018;25:1855-1869 pubmed publisher
Goretsky T, Bradford E, Ye Q, Lamping O, Vanagunas T, Moyer M, et al. Beta-catenin cleavage enhances transcriptional activation. Sci Rep. 2018;8:671 pubmed publisher
Alshareef A, Gupta N, Zhang H, Wu C, Haque M, Lai R. High expression of β-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma. Sci Rep. 2017;7:16863 pubmed publisher
Yang Y, Xiong D, Pipathsouk A, Weiner O, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017;43:507-521.e4 pubmed publisher
Blakely C, Watkins T, Wu W, Gini B, Chabon J, McCoach C, et al. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017;49:1693-1704 pubmed publisher
Cho S. APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Oncol Lett. 2017;14:4845-4852 pubmed publisher
Tan W, Pan M, Liu H, Tian H, Ye Q, Liu H. Ergosterol peroxide inhibits ovarian cancer cell growth through multiple pathways. Onco Targets Ther. 2017;10:3467-3474 pubmed publisher
Long M, Lin H, Parvez S, Zhao Y, Poganik J, Huang P, et al. β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Cell Chem Biol. 2017;24:944-957.e7 pubmed publisher
Yukimori A, Oikawa Y, Morita K, Nguyen C, Harada H, Yamaguchi S, et al. Genetic basis of calcifying cystic odontogenic tumors. PLoS ONE. 2017;12:e0180224 pubmed publisher
Berwick D, Javaheri B, Wetzel A, Hopkinson M, Nixon Abell J, Grannò S, et al. Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling. Mol Neurodegener. 2017;12:9 pubmed publisher
Qu Y, Gharbi N, Yuan X, Olsen J, Blicher P, Dalhus B, et al. Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer. Proc Natl Acad Sci U S A. 2016;113:9339-44 pubmed publisher
Im J, Yoon S, Kim B, Ban H, Won K, Chung K, et al. DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes ?-catenin-mediated invasion. Biochim Biophys Acta. 2016;1859:1449-1458 pubmed publisher
Yoshino Y, Ishioka C. Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Sci Rep. 2015;5:13249 pubmed publisher
Deng W, Vanderbilt D, Lin C, Martin K, Brundage K, Ruppert J. SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci. 2015;128:1123-38 pubmed publisher
Zhang M, Mahoney E, Zuo T, Manchanda P, Davuluri R, Kirschner L. Protein kinase A activation enhances β-catenin transcriptional activity through nuclear localization to PML bodies. PLoS ONE. 2014;9:e109523 pubmed publisher
Schmidt M, Donninger H, Clark G. Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A. J Biol Chem. 2014;289:31102-10 pubmed publisher
Ng O, Erbilgin Y, Firtina S, Celkan T, Karakas Z, Aydogan G, et al. Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia. Blood Cancer J. 2014;4:e192 pubmed publisher
Chen L, Li M, Li Q, Wang C, Xie S. DKK1 promotes hepatocellular carcinoma cell migration and invasion through ?-catenin/MMP7 signaling pathway. Mol Cancer. 2013;12:157 pubmed publisher
Ahrens M, Romereim S, Dudley A. A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn. 2011;240:2060-8 pubmed publisher
Kolligs F, Hu G, Dang C, Fearon E. Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol. 1999;19:5696-706 pubmed
product information
Catalog Number :
16828
Product Name :
human beta-catenin pcDNA3
article :
doi
id2057
pubmed_id10409758
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
This is a wild type beta-catenin in pcDNA3.
growth strain :
Mammalian expression of human beta-catenin with Flag tag
origin :
37
pi :
alt_names
CTNNB1
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5BamHI
promoter
sequencing_primer_3BGH rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCTNNB, EVR7, MRD19, NEDSDV, armadillo
geneCTNNB1
id1499
genbank_ids
mutation
namebeta-catenin
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagFlag
resistance markers :
144
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA