This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
c-myc promoter (Del 4)
catalog :
16604
citations: 9
Reference
Valiuska S, Psaras A, No xe9 V, Brooks T, Ciudad C. Targeting MYC Regulation with Polypurine Reverse Hoogsteen Oligonucleotides. Int J Mol Sci. 2022;24: pubmed publisher
Keller J, Hymøller K, Thorsager M, Hansen N, Erlandsen J, Tesauro C, et al. Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation. Nucleic Acids Res. 2022;: pubmed publisher
Psaras A, Chang K, Hao T, Brooks T. Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi. Molecules. 2021;26: pubmed publisher
Jana S, Panda D, Saha P, Pantos D, Dash J. Dynamic Generation of G-quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nano-platform. J Med Chem. 2018;: pubmed publisher
Dutta D, Debnath M, Muller D, Paul R, Das T, Bessi I, et al. Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex. Nucleic Acids Res. 2018;46:5355-5365 pubmed publisher
Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J. Human Telomeric G-Quadruplex Selective Fluoro-Isoquinolines Induce Apoptosis in Cancer Cells. Bioconjug Chem. 2018;29:1141-1154 pubmed publisher
Hao T, Gaerig V, Brooks T. Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex. Nucleic Acids Res. 2016;44:11013-11023 pubmed
Trinh B, Barengo N, Naora H. Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-? cytostatic program and blocks the antiproliferative effect of TGF-?. Oncogene. 2011;30:2718-29 pubmed publisher
He T, Sparks A, Rago C, Hermeking H, Zawel L, da Costa L, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281:1509-12 pubmed
product information
Catalog Number :
16604
Product Name :
c-myc promoter (Del 4)
article :
doi10.1126/science.281.5382.1509
id1865
pubmed_id9727977
bacterial resistance :
Ampicillin
cloning :
backbonepBV-Luc
backbone_mutation
backbone_originVogelstein Lab
backbone_size4867
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Luciferase
growth notes :
See Author's Map and article for more information.
origin :
37
pi :
alt_names
MYC
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3LucNRev
sequencing_primer_5n/a
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMRTL, MYCC, bHLHe39, c-Myc
geneMYC
id4609
genbank_ids
mutationDel-4 (PvuII->PvuII). The first PvuII site is at -484 on the promoter.
namec-myc promoter (Del 4)
shRNA_sequence
size800
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagluciferase
resistance markers :
553
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA