This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HER2 WT
catalog :
16257
citations: 30
Reference
Sailer C, Hong Y, Dahal A, Ryan A, Mir S, Gerber S, et al. PD-1Hi CAR-T cells provide superior protection against solid tumors. Front Immunol. 2023;14:1187850 pubmed publisher
Corogeanu D, Zaki K, Beavil A, Arnold J, Diebold S. Antibody conjugates for targeted delivery of Toll-like receptor 9 agonist to the tumor tissue. PLoS ONE. 2023;18:e0282831 pubmed publisher
Kollara A, Burt B, Ringuette M, Brown T. The adaptor protein VEPH1 interacts with the kinase domain of ERBB2 and impacts EGF signaling in ovarian cancer cells. Cell Signal. 2023;106:110634 pubmed publisher
Yu B, Shi Q, Belk J, Yost K, Parker K, Li R, et al. Engineered cell entry links receptor biology with single-cell genomics. Cell. 2022;185:4904-4920.e22 pubmed publisher
Godfrey J, Hejazi D, Du X, Wei C, Rao E, Gomez C. HER2 c-Terminal Fragments Are Expressed via Internal Translation of the HER2 mRNA. Int J Mol Sci. 2022;23: pubmed publisher
Hart V, Silipo M, Satam S, Gautrey H, Kirby J, Tyson Capper A. HER2-PI9 and HER2-I12: two novel and functionally active splice variants of the oncogene HER2 in breast cancer. J Cancer Res Clin Oncol. 2021;: pubmed publisher
Kundumani Sridharan V, Subramani J, Owens C, Das K. Nrg1β Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy. Arterioscler Thromb Vasc Biol. 2021;41:2293-2314 pubmed publisher
Chen Y, Wang R, Huang S, Henson E, Bi J, Gibson S. Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells. Cancers (Basel). 2021;13: pubmed publisher
Yang Y, Leonard M, Luo Z, Yeo S, Bick G, Hao M, et al. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell Rep. 2021;34:108822 pubmed publisher
Yoshioka H, Ramakrishnan S, Shim J, Suzuki A, Iwata J. Excessive All-Trans Retinoic Acid Inhibits Cell Proliferation Through Upregulated MicroRNA-4680-3p in Cultured Human Palate Cells. Front Cell Dev Biol. 2021;9:618876 pubmed publisher
Jeon I, Lee J, Shin K, Kang T, Park M, Seo H, et al. Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses. Vaccines (Basel). 2020;8: pubmed publisher
Jung D, Bae Y, Kim J, Shin Y, Jeung H. HER2 Regulates Cancer Stem Cell Activities via the Wnt Signaling Pathway in Gastric Cancer Cells. Oncology. 2019;97:311-318 pubmed publisher
Wang W, Gao Y, Hai J, Yang J, Duan S. HER2 decreases drug sensitivity of ovarian cancer cells via inducing stem cell-like property in an NFκB-dependent way. Biosci Rep. 2019;39: pubmed publisher
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, et al. Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. Breast Cancer Res. 2018;20:112 pubmed publisher
Kurmi K, Hitosugi S, Yu J, Boakye Agyeman F, Wiese E, Larson T, et al. Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway. Cell Metab. 2018;28:833-847.e8 pubmed publisher
Yin J, Albers A, Smith T, Riddell G, Richards J. Differential regulation of human monocytes and NK cells by antibody-opsonized tumors. Cancer Immunol Immunother. 2018;67:1239-1250 pubmed publisher
Carpenter R, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, et al. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. 2017;8:73947-73963 pubmed publisher
Napolitano S, Martini G, Martinelli E, Belli V, Parascandolo A, Laukkanen M, et al. Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation. Oncotarget. 2017;8:67592-67604 pubmed publisher
Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, et al. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. 2018;32:73-82 pubmed publisher
Dai X, He Y, Yao W, Gao X. Establishment of a spontaneous metastasis tumor model for human ErbB-2 vaccine. Biomed Pharmacother. 2017;88:991-998 pubmed publisher
Wielgos M, Rajbhandari R, Cooper T, Wei S, Nozell S, Yang E. Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors. Mol Cancer Res. 2017;15:340-347 pubmed publisher
Pramanik A, Laha D, Dash S, Chattopadhyay S, Roy S, Das D, et al. An in-vivo study for targeted delivery of copper-organic complex to breast cancer using chitosan polymer nanoparticles. Mater Sci Eng C Mater Biol Appl. 2016;68:327-337 pubmed publisher
Ma S, Henson E, Chen Y, Gibson S. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307 pubmed publisher
Zhu M, Yao X, Wu M, Qian H, Wu Y, Chen Y. Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells. Mol Med Rep. 2016;13:1909-13 pubmed publisher
Huang W, Wu Q, Zhang M, Kong Y, Cao P, Zheng W, et al. Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib. Cancer Lett. 2015;356:862-71 pubmed publisher
Hosonaga M, Arima Y, Sugihara E, Kohno N, Saya H. Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells. Cancer Sci. 2014;105:779-87 pubmed publisher
Carpenter R, Paw I, Dewhirst M, Lo H. Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Oncogene. 2015;34:546-57 pubmed publisher
Slanina H, Mündlein S, Hebling S, Schubert Unkmeir A. Role of epidermal growth factor receptor signaling in the interaction of Neisseria meningitidis with endothelial cells. Infect Immun. 2014;82:1243-55 pubmed publisher
Merkhofer E, Cogswell P, Baldwin A. Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha. Oncogene. 2010;29:1238-48 pubmed publisher
Li Y, Pan Y, Wei Y, Cheng X, Zhou B, Tan M, et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 2004;6:459-69 pubmed
product information
Catalog Number :
16257
Product Name :
HER2 WT
article :
doi10.1016/j.ccr.2004.09.027
id1776
pubmed_id15542430
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3HindIII
cloning_site_5HindIII
promoter
sequencing_primer_3BGHrev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)
geneERBB2
id2064
genbank_ids
mutation
nameHER2
shRNA_sequence
size4400
species
9606
Homo sapiens
tags
resistance markers :
215
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA