This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3 MDM2 WT
catalog :
16233
citations: 16
Reference
Cullot G, Boutin J, Fayet S, Prat F, Rosier J, Cappellen D, et al. Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9. Nat Commun. 2023;14:4072 pubmed publisher
Xiang W, Yang Y, Weng L, Ye Z, Ding P, Li H, et al. Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1. Int Immunopharmacol. 2023;118:110085 pubmed publisher
Li M, Zhong A, Wu Y, Sidharta M, Beaury M, Zhao X, et al. Transient inhibition of p53 enhances prime editing and cytosine base-editing efficiencies in human pluripotent stem cells. Nat Commun. 2022;13:6354 pubmed publisher
Niu X, Cui H, Gu X, Wu T, Sun M, Zhou C, et al. Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3. Front Oncol. 2022;12:837980 pubmed publisher
Cheng F, Dou J, Zhang Y, Wang X, Wei H, Zhang Z, et al. Urolithin A Inhibits Epithelial-Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway. Onco Targets Ther. 2021;14:3199-3208 pubmed publisher
Foster D, Chang H, Haswell J, Gregory R, Slack F. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020;:1-13 pubmed publisher
Park J, Park S, Lee Y, Park H, Oh S. PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. FEBS Open Bio. 2020;10:937-950 pubmed publisher
Niederkorn M, Hueneman K, Choi K, Varney M, Romano L, Pujato M, et al. TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Cell Rep. 2020;30:2776-2790.e6 pubmed publisher
Yang Hartwich Y, Tedja R, Roberts C, Goodner Bingham J, Cardenas C, Gurea M, et al. p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT. Mol Cancer Res. 2019;17:153-164 pubmed publisher
Mungamuri S, Qiao R, Yao S, Manfredi J, Gu W, Aaronson S. USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Cell Rep. 2016;14:2528-37 pubmed publisher
Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, et al. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2016;30:1120-34 pubmed publisher
Yang Hartwich Y, Soteras M, Lin Z, Holmberg J, Sumi N, Craveiro V, et al. p53 protein aggregation promotes platinum resistance in ovarian cancer. Oncogene. 2015;34:3605-16 pubmed publisher
Bhattacharya S, Ghosh M. HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. FEBS J. 2014;281:3061-78 pubmed publisher
Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, et al. Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012;209:2467-83 pubmed publisher
Lai C, Tsai A, Chen M, Chang L, Sun H, Chang Y, et al. Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. PLoS ONE. 2012;7:e42192 pubmed publisher
Zhou B, Liao Y, Xia W, Zou Y, Spohn B, Hung M. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol. 2001;3:973-82 pubmed
product information
Catalog Number :
16233
Product Name :
pcDNA3 MDM2 WT
article :
doi10.1038/ncb1101-973
id1766
pubmed_id11715018
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5BamHI
promoter
sequencing_primer_3BGHrev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesACTFS, HDMX, LSKB, hdm2
geneMDM2
id4193
genbank_ids
mutation
nameMDM2
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
resistance markers :
215
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA