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product summary
company name :
Addgene
product type :
cDNA
product name :
hSERT pcDNA3
catalog :
15483
citations: 9
Reference
Blom T, Meinsma R, di Summa F, van den Akker E, van Kuilenburg A, Hansen M, et al. Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes. EJNMMI Res. 2021;11:81 pubmed publisher
Jensen O, Rafehi M, Gebauer L, Brockmoller J. Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?. Front Pharmacol. 2020;11:609811 pubmed publisher
Ihara M, Zhang H, Ihara M, Kato D, Tanaka H. Proposal for fluorescence-based in vitro assay using human and zebrafish monoamine transporters to detect biological activities of antidepressants in wastewater. Sci Total Environ. 2021;770:144665 pubmed publisher
Sakai M, Nagayasu K, Shibui N, Andoh C, Takayama K, Shirakawa H, et al. Prediction of pharmacological activities from chemical structures with graph convolutional neural networks. Sci Rep. 2021;11:525 pubmed publisher
Ragu Varman D, Jayanthi L, Ramamoorthy S. Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. J Neurochem. 2020;: pubmed publisher
Blom T, Meinsma R, Rutgers M, Buitenhuis C, Dekken Van den Burg M, van Kuilenburg A, et al. Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake. EJNMMI Res. 2020;10:78 pubmed publisher
Brimson J, Akula K, Abbas H, Ferry D, Kulkarni S, Russell S, et al. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Sci Rep. 2020;10:9251 pubmed publisher
Cumming P, Maschauer S, Riss P, Tschammer N, Fehler S, Heinrich M, et al. Radiosynthesis and validation of ¹?F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain. J Cereb Blood Flow Metab. 2014;34:1148-56 pubmed publisher
Ramamoorthy S, Bauman A, Moore K, Han H, Yang Feng T, Chang A, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A. 1993;90:2542-6 pubmed
product information
Catalog Number :
15483
Product Name :
hSERT pcDNA3
article :
doi10.1073/pnas.90.6.2542
id1568
pubmed_id7681602
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
serotonin transporter
5HT transporter
solute carrier family 6 member 4 (SLC6A4)
cloning
clone_methodRestriction Enzyme
cloning_site_3XhoI
cloning_site_5NotI
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliases5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
geneSLC6A4
id6532
genbank_ids
mutation
namehSERT
shRNA_sequence
size2500
species
9606
Homo sapiens
tags
resistance markers :
39
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA