This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
LB322 (Bcl-2 from ATG to -3934)
catalog :
15381
citations: 12
Reference
Yu J, Han L, Yang F, Zhao M, Zhou H, Hu L. SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy. Bioengineered. 2022;13:14125-14137 pubmed publisher
Kumar S, Ramamurthy C, Choudhary D, Sekar A, Patra A, Bhavesh N, et al. Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1. Sci Rep. 2022;12:5019 pubmed publisher
Zhan H, Qin R, Li Y, Liu M, Gan L. TFEB promotes BCL-2 expression by upregulating its promoter activity in the t(6;11) translocation renal cell carcinomas. Am J Transl Res. 2021;13:8804-8818 pubmed
Li Y, Zhang B, Xiang L, Xia S, Kucuk O, Deng X, et al. TGF-β causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization. Theranostics. 2020;10:7656-7670 pubmed publisher
Kavazović I, Han H, Balzaretti G, Slinger E, Lemmermann N, ten Brinke A, et al. Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity. PLoS Biol. 2020;18:e3000648 pubmed publisher
Kim S, Ko D, Lee Y, Jang S, Lee Y, Lee I, et al. Anti-cancer activity of the novel 2-hydroxydiarylamide derivatives IMD-0354 and KRT1853 through suppression of cancer cell invasion, proliferation, and survival mediated by TMPRSS4. Sci Rep. 2019;9:10003 pubmed publisher
Dutta D, Debnath M, Muller D, Paul R, Das T, Bessi I, et al. Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex. Nucleic Acids Res. 2018;46:5355-5365 pubmed publisher
Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J. Human Telomeric G-Quadruplex Selective Fluoro-Isoquinolines Induce Apoptosis in Cancer Cells. Bioconjug Chem. 2018;29:1141-1154 pubmed publisher
Sun Y, Lu F, Han X, Ji M, Zhou Y, Zhang A, et al. MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1. Oncotarget. 2016;7:25276-90 pubmed publisher
Wang X, Zhou M, Fu Y, Sun T, Chen J, Qin X, et al. RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2. PLoS ONE. 2016;11:e0152142 pubmed publisher
Zhao R, Han C, Eisenhauer E, Kroger J, Zhao W, Yu J, et al. DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells. Mol Cancer Res. 2014;12:370-80 pubmed publisher
Heckman C, Mehew J, Ying G, Introna M, Golay J, Boxer L. A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells. J Biol Chem. 2000;275:6499-508 pubmed
product information
Catalog Number :
15381
Product Name :
LB322 (Bcl-2 from ATG to -3934)
article :
doi10.1074/jbc.275.9.6499
id1551
pubmed_id10692454
bacterial resistance :
Ampicillin
cloning :
backbonepBluescript II KS(+)
backbone_mutation
backbone_origin
backbone_size6000
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Bacterial Expression
Luciferase
origin :
37
pi :
alt_names
Bcl-2
cloning
clone_methodRestriction Enzyme
cloning_site_3HindIII
cloning_site_5BamHI
promoter
sequencing_primer_3T7
sequencing_primer_5T3
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBcl-2, PPP1R50
geneBCL2
id596
genbank_ids
mutationBcl-2 fragment from ATG to -3934 with both P1 and P2
nameB-cell lymphoma/leukemia-2
shRNA_sequence
size3926
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagLuciferase
resistance markers :
49
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA