This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabe-Puro-Myr-Flag-AKT1
catalog :
15294
citations: 20
Reference
Rose M, Nassar K, Sharma V, Schweppe R. AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and MEK1/2 inhibition. Med Oncol. 2023;40:299 pubmed publisher
Rose M, Espinoza V, Hoff K, Pike L, Sharma V, Hofmann M, et al. BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. Cancers (Basel). 2023;15: pubmed publisher
Demir M, Cizmecioglu O. ZAP70 Activation Compensates for Loss of Class IA PI3K Isoforms Through Activation of the JAK-STAT3 Pathway. Cancer Diagn Progn. 2022;2:391-404 pubmed publisher
Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, et al. ZNF768 links oncogenic RAS to cellular senescence. Nat Commun. 2021;12:4841 pubmed publisher
Li J, Kovach A, DeMonia M, Slemmons K, Oristian K, Chen C, et al. Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence. Sci Rep. 2021;11:16505 pubmed publisher
Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher
Strittmatter B, Jerde T, Hollenhorst P. Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells. PLoS Genet. 2021;17:e1009708 pubmed publisher
Scarpa M, Singh P, Bailey C, Lee J, Kapoor S, Lapidus R, et al. PP2A-activating drugs enhance FLT3 inhibitor efficacy through AKT inhibition-dependent GSK-3β-mediated c-Myc and Pim-1 proteasomal degradation. Mol Cancer Ther. 2021;: pubmed publisher
Chan S, Smith E, Gao Y, Kwan J, Blum B, Tilston Lünel A, et al. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020;8:608044 pubmed publisher
Jafari N, Zheng Q, Li L, Li W, Qi L, Xiao J, et al. p70S6K1 (S6K1)-mediated Phosphorylation Regulates Phosphatidylinositol 4-Phosphate 5-Kinase Type I ? Degradation and Cell Invasion. J Biol Chem. 2016;291:25729-25741 pubmed
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, et al. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res. 2016;26:1112-1130 pubmed publisher
Yim N, Ryu S, Choi K, Lee K, Lee S, Choi H, et al. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Nat Commun. 2016;7:12277 pubmed publisher
Hanaford A, Archer T, Price A, Kahlert U, Maciaczyk J, Nikkhah G, et al. DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. Clin Cancer Res. 2016;22:3903-14 pubmed publisher
Li Y, Li S, Ho C, Chang Y, Tan K, Chung T, et al. Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. Cancer Biol Ther. 2016;17:48-64 pubmed publisher
Tancioni I, Miller N, Uryu S, Lawson C, Jean C, Chen X, et al. FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Res. 2015;17:47 pubmed publisher
Hamilton G, Abraham A, Morton J, Sampson O, Pefani D, Khoronenkova S, et al. AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget. 2014;5:6142-67 pubmed
Wang C, Qin L, Manes T, Kirkiles Smith N, Tellides G, Pober J. Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. J Exp Med. 2014;211:395-404 pubmed publisher
Byles V, Covarrubias A, Ben Sahra I, Lamming D, Sabatini D, Manning B, et al. The TSC-mTOR pathway regulates macrophage polarization. Nat Commun. 2013;4:2834 pubmed publisher
Marina M, Wang L, Conrad S. The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells. Cell Commun Signal. 2012;10:18 pubmed publisher
Boehm J, Zhao J, Yao J, Kim S, Firestein R, Dunn I, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007;129:1065-79 pubmed
product information
Catalog Number :
15294
Product Name :
pBabe-Puro-Myr-Flag-AKT1
article :
doi10.1016/j.cell.2007.03.052
id1529
pubmed_id17574021
bacterial resistance :
Ampicillin
cloning :
backbonepBabe-puro
backbone_mutation
backbone_origin
backbone_size5100
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3SnaBI
cloning_site_5BglII/BamHI
promoter
sequencing_primer_3
sequencing_primer_5MSCV
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesAKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
geneAKT1
id207
genbank_ids
mutation
nameAKT1
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
locationN terminal on insert
tagMyr-Flag
resistance markers :
184
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA