This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabe-Puro-IKBalpha-mut (super repressor)
catalog :
15291
citations: 27
Reference
Wang Z, Wu S, Chen X, Liang J, Xue F, Cho W, et al. PFKP confers chemoresistance by upregulating ABCC2 transporter in non-small cell lung cancer. Transl Lung Cancer Res. 2023;12:2294-2309 pubmed publisher
Raynard C, Ma X, Huna A, Tessier N, Massemin A, Zhu K, et al. NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells. Aging Cell. 2022;:e13632 pubmed publisher
Yin K, Patten D, Gough S, de Barros Gonçalves S, Chan A, Olan I, et al. Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance. Genes Dev. 2022;36:533-549 pubmed publisher
López Antona I, Contreras Jurado C, Luque Martín L, Carpintero Leyva A, González Méndez P, Palmero I. Dynamic regulation of myofibroblast phenotype in cellular senescence. Aging Cell. 2022;21:e13580 pubmed publisher
Oreskovic E, Wheeler E, Mengwasser K, Fujimura E, Martin T, Tothova Z, et al. Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Huang H, Lai Y, Liao C, Yang W, Huang K, Lee I, et al. Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro. EBioMedicine. 2021;74:103712 pubmed publisher
Di Giorgio E, Paluvai H, Dalla E, Ranzino L, Renzini A, Moresi V, et al. HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. Genome Biol. 2021;22:129 pubmed publisher
Morel K, Hamid A, Clohessy J, Pandell N, Ellis L, Sweeney C. NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants. Mol Cancer Res. 2021;19:1137-1145 pubmed publisher
Huang H, Cai B, Suen C, Lee H, Hwang M, Liu F, et al. BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells. Cells. 2020;9: pubmed publisher
DeSisto J, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, et al. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma. Mol Cancer Ther. 2020;19:540-551 pubmed publisher
Huang H, Chao C, Wu P, Chung H, Lee H, Suen C, et al. Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers. Biochim Biophys Acta Gene Regul Mech. 2019;1862:173-183 pubmed publisher
Yu C, Chen S, Guo Y, Sun C. Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway. Theranostics. 2018;8:3224-3236 pubmed publisher
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discov. 2018;8:850-865 pubmed publisher
Yu D, Qin Y, Jun Qiang L, Shun Lin G. CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-?B pathway in human non-small cell lung cancer. Biomed Pharmacother. 2018;103:1658-1663 pubmed publisher
Warnier M, Flaman J, Chouabe C, Wiel C, Gras B, Griveau A, et al. The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. Aging Cell. 2018;17:e12736 pubmed publisher
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Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016;30:1837-51 pubmed publisher
Su X, Wang J, Chen W, Li Z, Fu X, Yang A. Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway. Oncotarget. 2016;7:9939-50 pubmed publisher
Trinh B, Barengo N, Kim S, Lee J, Zweidler McKay P, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling. J Cell Sci. 2015;128:3055-67 pubmed publisher
Xing S, Zhang B, Hua R, Tai W, Zeng Z, Xie B, et al. URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway. BMC Cancer. 2015;15:368 pubmed publisher
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Boehm J, Zhao J, Yao J, Kim S, Firestein R, Dunn I, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007;129:1065-79 pubmed
product information
Catalog Number :
15291
Product Name :
pBabe-Puro-IKBalpha-mut (super repressor)
article :
doi10.1016/j.cell.2007.03.052
id1529
pubmed_id17574021
bacterial resistance :
Ampicillin
cloning :
backbonepBabe-puro
backbone_mutation
backbone_origin
backbone_size5100
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
origin :
37
pi :
alt_names
IKB alpha
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5BglII/BamHI
promoter
sequencing_primer_3
sequencing_primer_5MSCV
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesEDAID2, IKBA, MAD-3, NFKBI
geneNFKBIA
id4792
genbank_ids
mutationS32A/S36A: super-repressor allele (resistant to phosphorylation and degradation)
nameinhibitor of Kappa B alpha
shRNA_sequence
size1000
species
9606
Homo sapiens
tags
resistance markers :
184
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA