This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV5 TrkA
catalog :
15002
citations: 8
Reference
Higerd Rusli G, Tyagi S, Liu S, Dib Hajj F, Waxman S, Dib Hajj S. The fates of internalized NaV1.7 channels in sensory neurons: retrograde co-transport with other ion channels, axon-specific recycling, and degradation. J Biol Chem. 2022;:102816 pubmed publisher
Regua A, Aguayo N, Jalboush S, Doheny D, Manore S, Zhu D, et al. TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers. Cancers (Basel). 2021;13: pubmed publisher
Ahmed F, Zapata Mercado E, Rahman S, Hristova K. The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers. Biophys J. 2021;120:55-63 pubmed publisher
Ahmed F, Hristova K. Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands. Biochem J. 2018;475:3669-3685 pubmed publisher
Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, et al. TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. BMC Cancer. 2015;15:777 pubmed publisher
Wang T, Chiu H, Chang Y, Hsu T, Chiu I, Chen L. The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. PLoS ONE. 2011;6:e26433 pubmed publisher
Fujita Y, Takashima R, Endo S, Takai T, Yamashita T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2011;2:e198 pubmed publisher
Yano H, Cong F, Birge R, Goff S, Chao M. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. J Neurosci Res. 2000;59:356-64 pubmed
product information
Catalog Number :
15002
Product Name :
pCMV5 TrkA
article :
doi10.1002/(SICI)1097-4547(20000201)59:3<356::AID-JNR9>3.0.CO;2-G
id1423
pubmed_id10679771
bacterial resistance :
Ampicillin
cloning :
backbonepCMV5
backbone_mutation
backbone_origin
backbone_size4600
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
The mammalian expression plasmid for trkA was generated by subcloning of TrkA full-length cDNA into pCMV5 vector at the EcoRI site.
origin :
37
pi :
alt_names
Trk A
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5EcoRI
promoter
sequencing_primer_3
sequencing_primer_5CMV Forward
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
geneNTRK1
id4914
genbank_ids
mutationV289L
nameTrkA
shRNA_sequence
size2400
species
9606
Homo sapiens
tags
plasmid copy :
TrkA was originally from B Hempstead, and was generated in the lab of Dr. Moses Chao.
resistance markers :
36
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA