This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA GSK3 beta K85A pcDNA3
catalog :
14755
citations: 25
Reference
Wang W, Li J, Tan J, Wang M, Yang J, Zhang Z, et al. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nat Commun. 2021;12:476 pubmed publisher
Cortés Gómez M, Llorens Álvarez E, Alom J, Del Ser T, Avila J, Saez Valero J, et al. Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression. J Neurochem. 2020;: pubmed publisher
Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, et al. HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis. Cell Signal. 2020;75:109744 pubmed publisher
Ragu Varman D, Jayanthi L, Ramamoorthy S. Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. J Neurochem. 2020;: pubmed publisher
Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
Markussen L, Winther S, Wicksteed B, Hansen J. GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep. 2018;8:3469 pubmed publisher
Tong Y, Park S, Wu D, Harris T, Moskaluk C, Brautigan D, et al. Modulation of GSK3β autoinhibition by Thr-7 and Thr-8. FEBS Lett. 2018;592:537-546 pubmed publisher
Abd Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld R. GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10. Sci Rep. 2018;8:1352 pubmed publisher
Gozdz A, Nikolaienko O, Urbanska M, Cymerman I, Sitkiewicz E, Blazejczyk M, et al. GSK3? and GSK3? Phosphorylate Arc and Regulate its Degradation. Front Mol Neurosci. 2017;10:192 pubmed publisher
Hinds T, Burns K, Hosick P, McBeth L, Nestor Kalinoski A, Drummond H, et al. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. J Biol Chem. 2016;291:25179-25191 pubmed
Zhang C, Hou B, Yu S, Chen Q, Zhang N, Li H. HGF alleviates high glucose-induced injury in podocytes by GSK3? inhibition and autophagy restoration. Biochim Biophys Acta. 2016;1863:2690-2699 pubmed publisher
Guo X, Snider W, Chen B. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. elife. 2016;5:e11903 pubmed publisher
Ngkelo A, Hoffmann R, Durham A, Marwick J, Brandenburg S, de Bruin H, et al. Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1112-23 pubmed publisher
Metge B, Mitra A, Chen D, Shevde L, Samant R. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015;5:11995 pubmed publisher
Horbach T, Chi T, Götz C, Sharma S, Juffer A, Dimova E, et al. GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. PLoS ONE. 2014;9:e107914 pubmed publisher
Levin Gromiko U, Koshelev V, Kushnir P, Fedida Metula S, Voronov E, Fishman D. Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid. Carcinogenesis. 2014;35:2555-66 pubmed publisher
Gonzalez O, Assfalg R, Koch S, Schelling A, Meena J, Kraus J, et al. Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Nat Commun. 2014;5:4599 pubmed publisher
Kubota K, Seno T, Konishi Y. A low-density culture method of cerebellar granule neurons with paracrine support applicable for the study of neuronal morphogenesis. Brain Res. 2013;1539:15-23 pubmed publisher
Ramser E, Gan K, Decker H, Fan E, Suzuki M, Ferreira S, et al. Amyloid-? oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Mol Biol Cell. 2013;24:2494-505 pubmed publisher
Patel R, Gao M, Ahmad I, Fleming J, Singh L, Rai T, et al. Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest. 2013;123:1157-75 pubmed publisher
Benseddik K, Sen Nkwe N, Daou P, Verdier Pinard P, Badache A. ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways. PLoS ONE. 2013;8:e55211 pubmed publisher
Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Arthritis Res Ther. 2012;14:R105 pubmed publisher
Saint Just Ribeiro M, Hansson M, Lindberg M, Popko Scibor A, Wallberg A. GSK3beta is a negative regulator of the transcriptional coactivator MAML1. Nucleic Acids Res. 2009;37:6691-700 pubmed publisher
Ibáñez A, Rio P, Casado J, Bueren J, Fernandez Luna J, Pipaon C. Elevated levels of IL-1beta in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation. Biochem J. 2009;422:161-70 pubmed publisher
Morel C, Carlson S, White F, Davis R. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol. 2009;29:3845-52 pubmed publisher
product information
Catalog Number :
14755
Product Name :
HA GSK3 beta K85A pcDNA3
article :
doi
id28238597
pubmed_id8382613
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5500
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Nru I site is added to the K->A mutation
origin :
37
pi :
alt_names
GSK3b
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliases
geneGSK3B
id2932
genbank_ids
mutationK85A. Kinase dead mutant.
nameGSK3 beta K85A
shRNA_sequence
size1300
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
resistance markers :
586
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA