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product summary
company name :
Addgene
product type :
cDNA
product name :
HA GSK3 beta wt pcDNA3
catalog :
14753
citations: 44
Reference
Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021;22: pubmed publisher
Wang W, Li J, Tan J, Wang M, Yang J, Zhang Z, et al. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nat Commun. 2021;12:476 pubmed publisher
Giovinazzo D, Bursać B, Sbodio J, Nalluru S, Vignane T, Snowman A, et al. Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Sá Pessoa J, Przybyszewska K, Vasconcelos F, Dumigan A, Frank C, Hobley L, et al. Klebsiella pneumoniae Reduces SUMOylation To Limit Host Defense Responses. MBio. 2020;11: pubmed publisher
Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, et al. HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis. Cell Signal. 2020;75:109744 pubmed publisher
Ragu Varman D, Jayanthi L, Ramamoorthy S. Glycogen synthase kinase-3ß supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. J Neurochem. 2020;: pubmed publisher
Asare Y, Campbell James T, Bokov Y, Yu L, Prestel M, El Bounkari O, et al. Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res. 2020;127:811-823 pubmed publisher
Lü L, Yakoumatos L, Ren J, Duan X, Zhou H, Gu Z, et al. JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling. FASEB J. 2020;: pubmed publisher
Alcántara Hernández R, Carmona Rosas G, Hernández Espinosa D, García Sáinz J. Glycogen Synthase Kinase-3 modulates α1A-adrenergic receptor action and regulation. Eur J Cell Biol. 2020;99:151072 pubmed publisher
Zhang B, Li Z, Zhang R, Hu Y, Jiang Y, Cao T, et al. PKCγ promotes axonal remodeling in the cortico-spinal tract via GSK3β/β-catenin signaling after traumatic brain injury. Sci Rep. 2019;9:17078 pubmed publisher
Saleh M, Rüschenbaum S, Welsch C, Zeuzem S, Moradpour D, Gouttenoire J, et al. Glycogen Synthase Kinase 3β Enhances Hepatitis C Virus Replication by Supporting miR-122. Front Microbiol. 2018;9:2949 pubmed publisher
Islam R, Kim J, Park Y, Cho J, Cap K, Kho A, et al. Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells. FASEB J. 2018;:fj201800917R pubmed publisher
St Amand M, Bond M, Riedy J, Comly M, Shiloach J, Hanover J. A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts. J Biol Chem. 2018;293:13673-13681 pubmed publisher
Pei S, Minhajuddin M, Adane B, Khan N, Stevens B, Mack S, et al. AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Cell Stem Cell. 2018;23:86-100.e6 pubmed publisher
Flamier A, El Hajjar J, Adjaye J, Fernandes K, Abdouh M, Bernier G. Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency. Cell Rep. 2018;23:2653-2666 pubmed publisher
Yang T, Sun Y, Mao L, Zhang M, Li Q, Zhang L, et al. Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation. Redox Biol. 2018;17:323-337 pubmed publisher
Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
Tong Y, Park S, Wu D, Harris T, Moskaluk C, Brautigan D, et al. Modulation of GSK3β autoinhibition by Thr-7 and Thr-8. FEBS Lett. 2018;592:537-546 pubmed publisher
Abd Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld R. GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10. Sci Rep. 2018;8:1352 pubmed publisher
Yang Y, Xiong D, Pipathsouk A, Weiner O, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017;43:507-521.e4 pubmed publisher
Alfano L, Caporaso A, Altieri A, Costa C, Forte I, Iannuzzi C, et al. NONO ubiquitination is mediated by FBW7 and GSK3 β via a degron lost upon chromosomal rearrangement in cancer. J Cell Physiol. 2018;233:4338-4344 pubmed publisher
Berwick D, Javaheri B, Wetzel A, Hopkinson M, Nixon Abell J, Grannò S, et al. Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling. Mol Neurodegener. 2017;12:9 pubmed publisher
Baehr C, Huntoon C, Hoang S, Jerde C, Karnitz L. Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival. J Biol Chem. 2016;291:26875-26885 pubmed publisher
Hinds T, Burns K, Hosick P, McBeth L, Nestor Kalinoski A, Drummond H, et al. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. J Biol Chem. 2016;291:25179-25191 pubmed
Gupta P, Srivastav S, Saha S, Das P, Ukil A. Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1. Cell Death Differ. 2016;23:1815-1826 pubmed publisher
Kolbe K, Bukhari H, Loosse C, Leonhardt G, Glotzbach A, Pawlas M, et al. Extensive nuclear sphere generation in the human Alzheimer's brain. Neurobiol Aging. 2016;48:103-113 pubmed publisher
Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
Zhang C, Hou B, Yu S, Chen Q, Zhang N, Li H. HGF alleviates high glucose-induced injury in podocytes by GSK3? inhibition and autophagy restoration. Biochim Biophys Acta. 2016;1863:2690-2699 pubmed publisher
Teixeira F, Randle S, Patel S, Mevissen T, Zenkeviciute G, Koide T, et al. Gsk3? and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Biochem J. 2016;473:3563-3580 pubmed
Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, et al. Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3? and ?-catenin. Biochem Pharmacol. 2016;115:18-27 pubmed publisher
Bai L, Yu Z, Zhang J, Yuan S, Liao C, Jeyabal P, et al. OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling. Oncotarget. 2016;7:10402-13 pubmed publisher
Tejeda Muñoz N, González Aguilar H, Santoyo Ramos P, Castañeda Patlán M, Robles Flores M. Glycogen Synthase Kinase 3β Is Positively Regulated by Protein Kinase Cζ-Mediated Phosphorylation Induced by Wnt Agonists. Mol Cell Biol. 2015;36:731-41 pubmed publisher
Horbach T, Chi T, Götz C, Sharma S, Juffer A, Dimova E, et al. GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. PLoS ONE. 2014;9:e107914 pubmed publisher
Lee D, Kim H, Lee Y, Kim S, Cha S, Ota I, et al. Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity. Nat Commun. 2014;5:4423 pubmed publisher
Eigler T, Ben Shlomo A, Zhou C, Khalafi R, Ren S, Melmed S. Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Mol Endocrinol. 2014;28:554-64 pubmed publisher
Kubota K, Seno T, Konishi Y. A low-density culture method of cerebellar granule neurons with paracrine support applicable for the study of neuronal morphogenesis. Brain Res. 2013;1539:15-23 pubmed publisher
Yin Y, Zhang X, Li Z, Deng L, Jiao G, Zhang B, et al. Glucocorticoid receptor ? regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of ?-catenin/TCF transcriptional activity. Neurobiol Dis. 2013;59:165-76 pubmed publisher
Frank C, Reguerio V, Rother M, Moranta D, Maeurer A, Garmendia J, et al. Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation. Cell Microbiol. 2013;15:1212-33 pubmed publisher
Feijs K, Kleine H, Braczynski A, Forst A, Herzog N, Verheugd P, et al. ARTD10 substrate identification on protein microarrays: regulation of GSK3? by mono-ADP-ribosylation. Cell Commun Signal. 2013;11:5 pubmed publisher
Mitra A, Menezes M, Pannell L, Mulekar M, Honkanen R, Shevde L, et al. DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3? to downregulate ?-catenin transcription target, osteopontin. Oncogene. 2012;31:4472-83 pubmed publisher
Yohn N, Bingaman C, Dumont A, Yoo L. Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3? mediated regulation of p21 in human urothelial carcinoma cells. BMC Urol. 2011;11:19 pubmed publisher
Tang X, Li M, Tucker L, Ramratnam B. Glycogen synthase kinase 3 beta (GSK3?) phosphorylates the RNAase III enzyme Drosha at S300 and S302. PLoS ONE. 2011;6:e20391 pubmed publisher
Morel C, Carlson S, White F, Davis R. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol. 2009;29:3845-52 pubmed publisher
He X, Saint Jeannet J, Woodgett J, Varmus H, Dawid I. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 1995;374:617-22 pubmed
product information
Catalog Number :
14753
Product Name :
HA GSK3 beta wt pcDNA3
article :
doi10.1038/374617a0
id1352
pubmed_id7715701
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5500
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Mammalian expression of human GSK3 beta with HA tag
origin :
37
pi :
alt_names
GSK3b
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5EcoRI
promoter
sequencing_primer_3
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliases
geneGSK3B
id2932
genbank_ids
mutation
nameGSK3 beta
shRNA_sequence
size1300
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
resistance markers :
586
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA