pCMV5 HA-TBRII (delta Cyt) | Addgene 14051 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Addgene

product type :

cDNA

product name :

pCMV5 HA-TBRII (delta Cyt)

catalog :

14051

citations: 6

Reference
Sheng W, Liu Y, Chakraborty D, Debo B, Shi Y. Simultaneous Inhibition of LSD1 and TGFβ Enables Eradication of Poorly Immunogenic Tumors with Anti-PD-1 Treatment. Cancer Discov. 2021;11:1970-1981 pubmed publisher
Varadaraj A, JENKINS L, Singh P, Chanda A, Snider J, Lee N, et al. TGF-Î² triggers rapid fibrillogenesis via a novel TÎ²RII-dependent fibronectin-trafficking mechanism. Mol Biol Cell. 2017;28:1195-1207 pubmed publisher
Chuang C, Greenside P, Rogers Z, Brady J, Yang D, Ma R, et al. Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Nat Med. 2017;23:291-300 pubmed publisher
JENKINS L, Singh P, Varadaraj A, Lee N, Shah S, Flores H, et al. Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling. J Biol Chem. 2016;291:25716-25728 pubmed
Wu M, Chen C, Lin Y, Jheng Y, Ho Y, Yang L, et al. Divergent signaling pathways cooperatively regulate TGF? induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014;12:22 pubmed publisher
Siegel P, Shu W, Cardiff R, Muller W, Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A. 2003;100:8430-5 pubmed

product information

Catalog Number :

14051

Product Name :

pCMV5 HA-TBRII (delta Cyt)

article :

doi	10.1073/pnas.0932636100
id	1227
pubmed_id	12808151

bacterial resistance :

Ampicillin

cloning :

backbone

pCMV5

backbone_mutation

backbone_origin

backbone_size

4700

promoter

sequencing_primer_3

sequencing_primer_5

vector_types

Mammalian Expression

origin :

pi :

alt_names

TGF beta receptor, type II

cloning

clone_method	Restriction Enzyme
cloning_site_3	BamHI
cloning_site_5	KpnI
promoter
sequencing_primer_3
sequencing_primer_5	CMV Forward
site_3_destroyed
site_5_destroyed

entrez_gene

aliases	AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TBR-ii, TBRII, TGFR-2, TGFbeta-RII, tbetaR-II
gene	TGFBR2
id	7048

genbank_ids

NM_003242

mutation

Dominant negative mutant. A stop codon was introduced just downstream of the transmembrane domain, rendering it incapable of phosphorylating and activating the type I receptor.

name

TGF beta rec II (delta cyt)

shRNA_sequence

size

600

species

9606

Homo sapiens