This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HDAC6 Flag
catalog :
13823
citations: 29
Reference
Dai H, Chang L, Yang S, Wang S, Su S, Yeh Y. HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability. Neoplasia. 2023;35:100845 pubmed publisher
Collins C, Kim S, Ventrella R, Carruzzo H, Wortman J, Han H, et al. Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation. Cell Rep. 2021;36:109556 pubmed publisher
Nomura Y, Nakano M, Woo Sung H, Han M, Pandey D. Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation. Front Physiol. 2021;12:675724 pubmed publisher
Bruce J, Bracken M, Evans E, Sherer N, Ahlquist P. ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. PLoS Pathog. 2021;17:e1009364 pubmed publisher
Mundhara N, Majumder A, Panda D. Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells. Biochem J. 2021;478:179-196 pubmed publisher
Peixoto E, Jin S, Thelen K, Biswas A, Richard S, Morleo M, et al. HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models. Am J Physiol Gastrointest Liver Physiol. 2020;318:G1022-G1033 pubmed publisher
Chao M, Chang L, Tu H, Chang C, Lai M, Chen Y, et al. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status. Clin Epigenetics. 2019;11:85 pubmed publisher
Tu H, Lin Y, Chao M, Sung T, Wu Y, Chen Y, et al. The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells. Clin Epigenetics. 2018;10:162 pubmed publisher
Zhang C, Gao J, Li M, Deng Y, Jiang C. p38? MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress. J Cell Sci. 2018;131: pubmed publisher
Kalogeropulou A, Zhao J, Bolliger M, Memou A, Narasimha S, Molitor T, et al. P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J. 2018;475:1271-1293 pubmed publisher
Wang Y, Zhang J, Su Y, Shen Y, Jiang D, Hou Y, et al. G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. Nat Commun. 2017;8:274 pubmed publisher
Hai Y, Christianson D. Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat Chem Biol. 2016;12:741-7 pubmed publisher
Liu H, Jiang F, Loo Y, Hsu S, Hsiang T, Marcotrigiano J, et al. Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6. EBioMedicine. 2016;9:195-206 pubmed publisher
Zalli D, Neff L, Nagano K, Shin N, Witke W, Gori F, et al. The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro. J Bone Miner Res. 2016;31:1701-12 pubmed publisher
Chen M, Huang H, Lai C, Lin Y, Liou J, Lai M, et al. Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma. Oncotarget. 2016;7:402-17 pubmed publisher
Nakashima H, Kaufmann J, Wang P, Nguyen T, Speranza M, Kasai K, et al. Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015;125:4269-80 pubmed publisher
Yang C, Liu Y, Dai H, Shiue Y, Tsai C, Huang M, et al. Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer. Oncotarget. 2015;6:30263-76 pubmed publisher
Forcioli Conti N, Estève D, Bouloumié A, Dani C, Peraldi P. The size of the primary cilium and acetylated tubulin are modulated during adipocyte differentiation: Analysis of HDAC6 functions in these processes. Biochimie. 2016;124:112-123 pubmed publisher
Meng Z, Jia L, Gan Y. PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. Oncogene. 2016;35:2333-44 pubmed publisher
Salian Mehta S, Xu M, McKinsey T, Tobet S, Wierman M. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem. 2015;290:14045-56 pubmed publisher
Huang H, Peng C, Lai M, Chen C, Lee H, Wang J, et al. Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Oncotarget. 2015;6:4976-91 pubmed
Hsieh I, Liou J, Lee H, Lai M, Li Y, Yang C. Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009. Cell Death Dis. 2014;5:e1166 pubmed publisher
Joo E, Yamada K. MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly. Nat Commun. 2014;5:3510 pubmed publisher
Shin H, Decotiis J, Giron M, Palmeri D, Lukac D. Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. J Virol. 2014;88:1281-92 pubmed publisher
Buchberger E, El Harchi M, Payrhuber D, Zommer A, Schauer D, Simonitsch Klupp I, et al. Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes. PLoS ONE. 2013;8:e76845 pubmed publisher
Wang J, Shih K, Wu Y, Wang A, Yang C. Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1? signaling in osteoarthritis fibroblast-like synoviocytes. Osteoarthritis Cartilage. 2013;21:1987-96 pubmed publisher
Gradilone S, Radtke B, Bogert P, Huang B, Gajdos G, Larusso N. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013;73:2259-70 pubmed publisher
Lee M, Koh A, Park D, Jang J, Kwak D, Jeon H, et al. Deacetylated ??-tubulin acts as a positive regulator of Rheb GTPase through increasing its GTP-loading. Cell Signal. 2013;25:539-51 pubmed publisher
Fischle W, Emiliani S, Hendzel M, Nagase T, Nomura N, Voelter W, et al. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J Biol Chem. 1999;274:11713-20 pubmed
product information
Catalog Number :
13823
Product Name :
HDAC6 Flag
article :
doi10.1074/jbc.274.17.11713
id3198
pubmed_id10206986
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1 +
backbone_mutation
backbone_originInvitrogen
backbone_size5500
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
cloned into a version of pcDNA3.1 that has been modified to include a C-terminal Flag tag (see author's map for details).
growth strain :
Mammalian expression of human histone deacetylase 6 with flag tag
origin :
37
pi :
alt_names
Histone Deacetylase 6
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5NotI
promoter
sequencing_primer_3BGH Reverse
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCPBHM, HD6, JM21, KDAC6, PPP1R90
geneHDAC6
id10013
genbank_ids
NM_006044
mutation
nameHDAC6
shRNA_sequence
size3600
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagflag
resistance markers :
547
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA