This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HDAC4 Flag
catalog :
13821
citations: 27
Reference
Shi F, de Fatima Silva F, Liu D, Patel H, Xu J, Zhang W, et al. Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning. Mol Metab. 2023;74:101753 pubmed publisher
Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Els xe4 sser S, Skodras A, et al. Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Nat Commun. 2022;13:1223 pubmed publisher
Bruce J, Bracken M, Evans E, Sherer N, Ahlquist P. ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. PLoS Pathog. 2021;17:e1009364 pubmed publisher
Kang H, Park Y, Lee J. Inhibition of alcohol-induced inflammation and oxidative stress by astaxanthin is mediated by its opposite actions in the regulation of sirtuin 1 and histone deacetylase 4 in macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:158838 pubmed publisher
Chao M, Chang L, Tu H, Chang C, Lai M, Chen Y, et al. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status. Clin Epigenetics. 2019;11:85 pubmed publisher
Brescia P, Schneider C, Holmes A, Shen Q, Hussein S, Pasqualucci L, et al. MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Cancer Cell. 2018;34:453-465.e9 pubmed publisher
Dodge Kafka K, Gildart M, Li J, Thakur H, Kapiloff M. Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes. J Mol Cell Cardiol. 2018;118:13-25 pubmed publisher
Kalogeropulou A, Zhao J, Bolliger M, Memou A, Narasimha S, Molitor T, et al. P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J. 2018;475:1271-1293 pubmed publisher
Chandran J, Sharp P, Karyka E, Aves Cruzeiro J, Coldicott I, Castelli L, et al. Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome. Sci Rep. 2017;7:14766 pubmed publisher
Wang Y, Zhang J, Su Y, Shen Y, Jiang D, Hou Y, et al. G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. Nat Commun. 2017;8:274 pubmed publisher
Chuang Y, Huang S, Hsu Y, Yu M, Ou G, Huang W, et al. WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade. Br J Pharmacol. 2017;174:2941-2961 pubmed publisher
Penrod R, Carreira M, Taniguchi M, Kumar J, Maddox S, Cowan C. Novel role and regulation of HDAC4 in cocaine-related behaviors. Addict Biol. 2018;23:653-664 pubmed publisher
Trazzi S, Fuchs C, Viggiano R, De Franceschi M, Valli E, Jedynak P, et al. HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder. Hum Mol Genet. 2016;25:3887-3907 pubmed publisher
Liu H, Jiang F, Loo Y, Hsu S, Hsiang T, Marcotrigiano J, et al. Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6. EBioMedicine. 2016;9:195-206 pubmed publisher
Kemler D, Dahley O, Roßwag S, Litfin M, Kassel O. The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts. Sci Rep. 2016;6:27746 pubmed publisher
Yen C, Chen J, Chang Y, Hsu Y, Chiu P, Shiue C, et al. Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade. Sci Rep. 2016;6:25082 pubmed publisher
Huang Y, Huang S, Hsu Y, Ou G, Huang W, Hsu M. The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death. Sci Rep. 2015;5:15900 pubmed publisher
Lee H, Song M, Seok Y, Kang S, Kim S, Kim I. Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor. PLoS ONE. 2015;10:e0136801 pubmed publisher
Chen S, Yin C, Lao T, Liang D, He D, Wang C, et al. AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle. 2015;14:2520-36 pubmed publisher
Huang H, Peng C, Lai M, Chen C, Lee H, Wang J, et al. Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Oncotarget. 2015;6:4976-91 pubmed
Rahman S, Housein Z, Dabrowska A, Mayán M, Boobis A, Hajji N. E2F1-mediated FOS induction in arsenic trioxide-induced cellular transformation: effects of global H3K9 hypoacetylation and promoter-specific hyperacetylation in vitro. Environ Health Perspect. 2015;123:484-92 pubmed publisher
Kritzer M, Li J, Passariello C, Gayanilo M, Thakur H, Dayan J, et al. The scaffold protein muscle A-kinase anchoring protein ? orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014;7:663-72 pubmed publisher
Duncan C, An M, Papanikolaou T, Rugani C, Vitelli C, Ellerby L. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener. 2013;8:42 pubmed publisher
Buchberger E, El Harchi M, Payrhuber D, Zommer A, Schauer D, Simonitsch Klupp I, et al. Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes. PLoS ONE. 2013;8:e76845 pubmed publisher
Wang J, Shih K, Wu Y, Wang A, Yang C. Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1? signaling in osteoarthritis fibroblast-like synoviocytes. Osteoarthritis Cartilage. 2013;21:1987-96 pubmed publisher
Chang H, Chen C, Hsu Y, Kuo W, Ou G, Chiu P, et al. Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Biochim Biophys Acta. 2013;1830:4053-64 pubmed publisher
Fischle W, Emiliani S, Hendzel M, Nagase T, Nomura N, Voelter W, et al. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p. J Biol Chem. 1999;274:11713-20 pubmed
product information
Catalog Number :
13821
Product Name :
HDAC4 Flag
article :
doi10.1074/jbc.274.17.11713
id3198
pubmed_id10206986
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1 +
backbone_mutation
backbone_originInvitrogen
backbone_size5500
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Cloned into a version of pcDNA3.1 that has been modified to include a C-terminal Flag tag (see author's map for details). The HDAC4 insert in this plasmid matches GenBank reference sequence NP_006028.1.
growth strain :
Mammalian expression of human histone deacetylase 4 with flag tag
origin :
37
pi :
alt_names
Histone Deacetylase A
HDACA
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, NEDCHF, NEDCHID
geneHDAC4
id9759
genbank_ids
NM_006037.2
NP_006028.1
mutation
nameHDAC4
shRNA_sequence
size3252
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagFlag
resistance markers :
547
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA