This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCDNA3-Flag MKK6(K82A)
catalog :
13519
citations: 9
Reference
Sellers J, Brooks A, Fernando S, Westenberger G, Junkins S, Smith S, et al. Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding. Nutrients. 2021;13: pubmed publisher
Fischer K, Fenzl A, Liu D, Dyar K, Kleinert M, Brielmeier M, et al. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. 2020;11:2306 pubmed publisher
Rahman S, Zhou W, Deiters A, Haugh J. Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. J Biol Chem. 2020;295:8494-8504 pubmed publisher
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
Quesada López T, Cereijo R, Turatsinze J, Planavila A, Cairó M, Gavaldà Navarro A, et al. The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun. 2016;7:13479 pubmed publisher
Li L, Gao G, Shankar J, Joshi B, Foster L, Nabi I. p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Mol Biol Cell. 2015;26:3828-40 pubmed publisher
Ribas F, Villarroya J, Hondares E, Giralt M, Villarroya F. FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. Biochem J. 2014;463:191-9 pubmed publisher
Blue E, Digiuseppe R, Derr Yellin E, Acosta J, Pay S, Hanenberg H, et al. Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res. 2014;75:266-72 pubmed publisher
Raingeaud J, Whitmarsh A, Barrett T, Derijard B, Davis R. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 1996;16:1247-55 pubmed
product information
Catalog Number :
13519
Product Name :
pCDNA3-Flag MKK6(K82A)
article :
doi
id1092
pubmed_id8622669
bacterial resistance :
Ampicillin
cloning :
backbonepCDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5446
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Please note there are 3 additional mutations found in the QC sequence that are not present in the NGS full sequencing result. These mutations have no affect on the plasmid function.
origin :
37
pi :
alt_names
MKK6
cloning
clone_methodRestriction Enzyme
cloning_site_3Xba I
cloning_site_5Hind III
promoter
sequencing_primer_3Sp6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
geneMAP2K6
id5608
genbank_ids
mutationLys-82Ala
nameMKK6(K82A)
shRNA_sequence
size1235
species
9606
Homo sapiens
tags
locationN terminal on insert
tagFlag
resistance markers :
106
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA