This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCDNA3-Flag MKK6(glu)
catalog :
13518
citations: 24
Reference
Sellers J, Brooks A, Fernando S, Westenberger G, Junkins S, Smith S, et al. Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding. Nutrients. 2021;13: pubmed publisher
Nordgaard C, Tollenaere M, Val A, Bekker Jensen D, Blasius M, Olsen J, et al. Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses. Int J Mol Sci. 2021;22: pubmed publisher
Kang J, Yan J, Ranjan K, Zhang X, Turner J, Abraham C. Myeloid Cell Expression of LACC1 is Required for Bacterial Clearance and Control of Intestinal Inflammation. Gastroenterology. 2020;: pubmed publisher
Rahman S, Zhou W, Deiters A, Haugh J. Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. J Biol Chem. 2020;295:8494-8504 pubmed publisher
Hori T, Saito K, Moore R, Flake G, Negishi M. Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. Mol Cancer Res. 2018;16:1309-1318 pubmed publisher
Basken J, Stuart S, Kavran A, Lee T, Ebmeier C, Old W, et al. Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018;17:550-564 pubmed publisher
Shah M, Smolko C, Kinicki S, Chapman Z, Brautigan D, Janes K. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Mol Cell Proteomics. 2017;16:S244-S262 pubmed publisher
Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S. Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner. J Cell Physiol. 2017;232:3317-3336 pubmed publisher
Cook P, Tabor G. Deciphering fact from artifact when using reporter assays to investigate the roles of host factors on L1 retrotransposition. Mob DNA. 2016;7:23 pubmed
Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed publisher
Hedl M, Yan J, Abraham C. IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016;16:2442-55 pubmed publisher
Liu X, Zhao Y, Peng S, Zhang S, Wang M, Chen Y, et al. BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells. Sci Rep. 2016;6:31049 pubmed publisher
Li L, Gao G, Shankar J, Joshi B, Foster L, Nabi I. p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Mol Biol Cell. 2015;26:3828-40 pubmed publisher
Li L, Hu J, He T, Zhang Q, Yang X, Lan X, et al. P38/MAPK contributes to endothelial barrier dysfunction via MAP4 phosphorylation-dependent microtubule disassembly in inflammation-induced acute lung injury. Sci Rep. 2015;5:8895 pubmed publisher
Thalheimer F, Wingert S, De Giacomo P, Haetscher N, Rehage M, Brill B, et al. Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells. Stem Cell Reports. 2014;3:34-43 pubmed publisher
Liu J, Han L, Li B, Yang J, Huen M, Pan X, et al. F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6). J Biol Chem. 2014;289:21508-18 pubmed publisher
Hu W, Yan Q, Fang Y, Qiu Z, Zhang S. Transient folate deprivation in combination with small-molecule compounds facilitates the generation of somatic cell-derived pluripotent stem cells in mice. J Huazhong Univ Sci Technolog Med Sci. 2014;34:151-156 pubmed publisher
Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll R, et al. The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity. J Exp Med. 2014;211:427-40 pubmed publisher
Schaeffer E, West R, Conine S, Lowrey C. Multiple physical stresses induce ?-globin gene expression and fetal hemoglobin production in erythroid cells. Blood Cells Mol Dis. 2014;52:214-24 pubmed publisher
Blue E, Digiuseppe R, Derr Yellin E, Acosta J, Pay S, Hanenberg H, et al. Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Pediatr Res. 2014;75:266-72 pubmed publisher
Bose A, Janes K. A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Mol Cell Proteomics. 2013;12:797-806 pubmed publisher
Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, et al. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. BMC Cell Biol. 2012;13:21 pubmed publisher
Pham H, Vincenti R, Slice L. COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Biochim Biophys Acta. 2008;1779:408-13 pubmed publisher
Raingeaud J, Whitmarsh A, Barrett T, Derijard B, Davis R. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 1996;16:1247-55 pubmed
product information
Catalog Number :
13518
Product Name :
pCDNA3-Flag MKK6(glu)
article :
doi
id1092
pubmed_id8622669
bacterial resistance :
Ampicillin
cloning :
backbonepCDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5446
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
MKK6
cloning
clone_methodRestriction Enzyme
cloning_site_3Xba I
cloning_site_5Hind III
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
geneMAP2K6
id5608
genbank_ids
U39656
mutationSer-207Glu Thr-211Glu
nameMKK6(glu)
shRNA_sequence
size1044
species
9606
Homo sapiens
tags
locationN terminal on insert
tagFlag
resistance markers :
106
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA