This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA-DEST47 PINK1 C-GFP
catalog :
13316
citations: 8
Reference
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher
Ma K, Fokkens M, van Laar T, Verbeek D. Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. NPJ Parkinsons Dis. 2021;7:113 pubmed publisher
Yu S, Du M, Yin A, Mai Z, Wang Y, Zhao M, et al. Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation. Int J Biochem Cell Biol. 2020;122:105720 pubmed publisher
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed publisher
Sun X, Duan Y, Qin C, Li J, Duan G, Deng X, et al. Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy. Cell Death Dis. 2018;9:953 pubmed publisher
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed publisher
Azkona G, Lopez de Maturana R, Del Río P, Sousa A, Vazquez N, Zubiarrain A, et al. LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1. Mol Neurobiol. 2018;55:506-516 pubmed publisher
Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller D, Petsko G, et al. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc Natl Acad Sci U S A. 2005;102:5703-8 pubmed
product information
Catalog Number :
13316
Product Name :
pcDNA-DEST47 PINK1 C-GFP
article :
doi10.1073/pnas.0500617102
id1025
pubmed_id15824318
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA-DEST47
backbone_mutation
backbone_originInvitrogen
backbone_size7780
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodGateway Cloning
cloning_site_3attR2
cloning_site_5attR1
promoter
sequencing_primer_3
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBRPK, PARK6
genePINK1
id65018
genbank_ids
mutation
namePINK1
shRNA_sequence
size1743
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagGFP
resistance markers :
89
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA