This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pFlag-CMV1-hMD2
catalog :
13028
citations: 8
Reference
Zhang P, Nguyen J, Abdulla F, Nelson A, Beckman J, Vercellotti G, et al. Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Front Immunol. 2021;12:632709 pubmed publisher
McKee H, Kajiwara C, Yamaguchi T, Ishii Y, Shimizu N, Ohara A, et al. Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-α via Toll-like receptors in macrophages. J Med Microbiol. 2021;70: pubmed publisher
Moraes Vieira P, Yore M, Sontheimer Phelps A, Castoldi A, Norseen J, Aryal P, et al. Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4. Proc Natl Acad Sci U S A. 2020;117:31309-31318 pubmed publisher
Belcher J, Zhang P, Nguyen J, Kiser Z, Nath K, Hu J, et al. Identification of a Heme Activation Site on the MD-2/TLR4 Complex. Front Immunol. 2020;11:1370 pubmed publisher
Choi I, Zhang Y, Seegobin S, Pruvost M, Wang Q, Purtell K, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020;11:1386 pubmed publisher
Lv X, Wang H, Su A, Xu S, Chu Y. Herpes simplex virus type 2 infection triggers AP-1 transcription activity through TLR4 signaling in genital epithelial cells. Virol J. 2018;15:173 pubmed publisher
Hosoki K, Redding D, Itazawa T, Chakraborty A, Tapryal N, Qian S, et al. Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways. J Allergy Clin Immunol. 2017;140:1436-1439.e5 pubmed publisher
Hosoki K, Boldogh I, Aguilera Aguirre L, Sun Q, Itazawa T, HAZRA T, et al. Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation. J Allergy Clin Immunol. 2016;137:1506-1513.e2 pubmed publisher
product information
Catalog Number :
13028
Product Name :
pFlag-CMV1-hMD2
article :
doi
id978
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepFlag-CMV
backbone_mutation
backbone_originSigma
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Please note that when compared to GenBank reference sequence NP_056179, the LY96 (MD-2) insert in this plasmid does not contain the signal peptide sequence (amino acids 1-16).
origin :
37
pi :
alt_names
LY96
cloning
clone_methodRestriction Enzyme
cloning_site_3unknown
cloning_site_5unknown
promoterCMV
sequencing_primer_3hGH-pA-R
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesESOP-1, MD-2, MD2, ly-96
geneLY96
id23643
genbank_ids
mutation
nameMD2
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFlag
resistance markers :
169
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA