This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5-myc-Rac1-T17N
catalog :
12984
citations: 8
Reference
Bianchi Smiraglia A, Wolff D, Marston D, Deng Z, Han Z, Moparthy S, et al. Regulation of local GTP availability controls RAC1 activity and cell invasion. Nat Commun. 2021;12:6091 pubmed publisher
Kim J, Kang W, Kang S, Park S, Kim J, Yang S, et al. Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Sci Rep. 2020;10:21018 pubmed publisher
Canales J, Cruz P, Diaz N, Riquelme D, Leiva Salcedo E, Cerda O. K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity. Cells. 2020;9: pubmed publisher
Zhou H, Cai L, Zhang X, Li A, Miao Y, Li Q, et al. ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients. Lab Invest. 2018;98:670-681 pubmed publisher
Orefice L, Shih C, Xu H, Waterhouse E, Xu B. Control of spine maturation and pruning through proBDNF synthesized and released in dendrites. Mol Cell Neurosci. 2016;71:66-79 pubmed publisher
Gao G, Wang W, Tadagavadi R, Briley N, Love M, Miller B, et al. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest. 2014;124:4989-5001 pubmed publisher
Chen P, Jian X, Yoon H, Randazzo P. ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. J Biol Chem. 2013;288:5849-60 pubmed publisher
Loh K, Leong W, Carlson M, Oskouian B, Kumar A, Fyrst H, et al. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS ONE. 2012;7:e37218 pubmed publisher
product information
Catalog Number :
12984
Product Name :
pRK5-myc-Rac1-T17N
article :
doi
id965
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepRK5-Myc
backbone_mutation
backbone_origin
backbone_size4750
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
Rac1
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5BamHI
promoter
sequencing_primer_3
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMIG5, MRD48, Rac-1, TC-25, p21-Rac1
geneRAC1
id5879
genbank_ids
AF498964
mutationT17N Dominant negative
nameRac1 DN
shRNA_sequence
size579
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagMyc
resistance markers :
45
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA